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Upregulation of MicroRNA-144 Suppresses Nrf2 Antioxidant Signaling Pathway in Patients with Severe COVID-19.
Iran J Allergy Asthma Immunol
February 2025
Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran AND Department of Applied Cell Sciences, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran AND Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
MicroRNAs (miRs) play a pivotal role in the pathogenesis of viral infections. It has been proven that the Nrf2 (NFE2 like bZIP transcription factor 2) antioxidant signaling pathway is inhibited in COVID-19 patients. Two microRNAs (MIR144 and MIR153-1) have been identified as important Nrf2 regulators.
View Article and Find Full Text PDFPreparation of sodium alginate antibacterial porous composite pads embedded with centrifugally spun nanofibers by freeze-drying and recasting for active food packaging.
Carbohydr Polym
May 2025
College of Food Science, Northeast Agricultural University, Harbin 150030, China. Electronic address:
In this study, nanofibers composed of ethyl cellulose (EC)/polyethylene oxide (PEO) impregnated with tea polyphenol (TP) were fabricated by the centrifugal spinning method. Subsequently, these nanofibers were incorporated into sodium alginate (SA) to generate porous composite pads with varying fiber contents. The porous composite pads were comprehensively characterized.
View Article and Find Full Text PDFPhosphoregulation of Microtubule Assembly and Disassembly for Phragmoplast Expansion During Plant Cytokinesis.
Bioessays
March 2025
Department of Plant Biology, College of Biological Sciences, University of California, Davis, California, USA.
Plant cytokinesis results in the formation of the cell plate by the phragmoplast which contains dynamic microtubules serving as the track for the delivery of cell wall builders included in Golgi vesicles. During the centrifugal process of cell plate assembly, new microtubules are assembled and bundled at the leading edge to prepare for vesicle transport while older microtubules are disassembled at the lagging edge upon the completion of vesicle delivery. The turnover of phragmoplast microtubules in this process is thought to be regulated by phosphorylation of the key microtubule bundling factor MAP65.
View Article and Find Full Text PDFBiomarkers in Skin Mucus for a Minimally Invasive Approach to Stress in Red Tilapia ( sp.) Fry.
Biology (Basel)
January 2025
Department of Animal Production, Faculty of Agrarian Sciences, Universidad Nacional de Colombia, Medellín Campus, Carrera 65 #59ª-110, Bloque 50 Of. 309 Nucleo El Volador, Medellín 050034, Colombia.
In a context where aquaculture continues to grow, it is essential to understand how culture conditions influence fish stress. The welfare of red tilapia fry ( sp.), weighing 0.
View Article and Find Full Text PDFEnzymatic Isolation of Skeletal Muscle Interstitial Extracellular Vesicles.
J Vis Exp
February 2025
Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Science, University of Georgia;
Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells to transport bioactive cargo, such as proteins, RNAs, and DNAs, for intercellular communication. Investigating EV-mediated crosstalk among cells in muscle homeostasis and diseases offers significant potential to enhance our understanding of muscle development, regeneration, and atrophy. However, current protocols for isolating skeletal muscle-derived EVs (SkM-EVs) face challenges in achieving high purity and yield, primarily due to difficulties in releasing EVs from muscle tissues without compromising cellular membranes.
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