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Assessment of free testosterone concentration.
J Steroid Biochem Mol Biol
June 2019
Department of Clinical Biochemistry, Manchester University Hospital NHS Trust, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Testosterone (T) is strongly bound to sex hormone binding globulin and measurement of free T may be more appropriate than measuring total serum T, according to the free hormone theory. This view remains controversial and it has its detractors who claim that little extra benefit is gained than simply measuring total T, but it is endorsed by recent clinical practice guidelines for investigation of androgen disorders in both men and women. Free T measurement is very challenging.
View Article and Find Full Text PDFQuantitative determination of testosterone levels with biolayer interferometry.
Chem Biol Interact
October 2017
School of Life Science and Technology, Changchun University of Science and Technology, 130022 Changchun, Jilin Province, PR China. Electronic address:
Natural and synthetic steroid hormones are widely spread in the environment and are considered as pollutants due to their endocrine activities, even at low concentrations, which are harmful to human health. To detect steroid hormones in the environment, a novel biosensor system was developed based on the principle of biolayer interferometry. Detection is based on changes in the interference pattern of white light reflected from the surface of an optical fiber with bound biomolecules.
View Article and Find Full Text PDFThe low dose gamma ionising radiation impact upon cooperativity of androgen-specific proteins.
J Environ Radioact
January 2014
Lab. of Biochemistry, Institute of Radiobiology, National Academy of Sciences of Belarus, Feduninskogo 4, Gomel 246007, Belarus.
The paper deals with effects of the ionising radiation (γ-IR, 0.5 Gy) upon serum testosterone (T), characteristics of testosterone-binding globulin (TeBG) and androgen receptor (AR) in parallel with observation of androgen (A) responsive enzyme activity - hexokinase (HK). The interdependence or relationships of T-levels with parameters of the proteins that provide androgenic regulation are consequently analyzed in post-IR dynamics.
View Article and Find Full Text PDFGenetic determinants of serum testosterone concentrations in men.
PLoS Genet
October 2011
Center for Bone and Arthritis Research, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as <300 ng/dl.
View Article and Find Full Text PDFThe effect of organochlorines and heavy metals on sex steroid-binding proteins in vitro in the plasma of nesting green turtles, Chelonia mydas.
J Comp Physiol B
July 2009
School of Biomedical Sciences, Anatomy and Developmental Biology, The University of Queensland, Brisbane, QLD 4072, Australia.
In this study on green turtles, Chelonia mydas, from Peninsular Malaysia, the effect of selected environmental toxicants was examined in vitro. Emphasis was placed on purported hormone-mimicking chemicals such as dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene, dieldrin, lead, zinc and copper. Five concentrations were used: high (1 mg/L), medium (10(-1) mg/L), low (10(-2) mg/L), very low (10(-6) mg/L) and control (diluted carrier solvent but no toxicants).
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