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Introduction Acute lymphoblastic leukemia (ALL) has suboptimal survival rates for adolescents and young adults (AYA) as compared to children. Very limited studies have been conducted on AYA patients in India. This study aimed to identify the cytogenetic and immunophenotype characteristics of B-cell ALL (B-ALL) in AYA patients and determine its correlation with clinicopathological parameters in the Southern India region.
View Article and Find Full Text PDFEur J Histochem
January 2024
National Academy of Sciences, Accademia dei Lincei, Rome.
This paper reviews some of the goals of our investigations published over the years on Rivista di Istochimica Normale e Patologica, Basic and Applied Histochemistry, and the European Journal of Histochemistry - EJH. In a series of papers, we published some of the basic cytochemical features of the sperm cytodifferentiation process for the first time. This was a conceptual and practical prerequisite to the in situ quantitative evaluation of sperm DNA content.
View Article and Find Full Text PDFBalkan J Med Genet
November 2020
Department of Medical Genetics, Pamukkale University, Denizli, Turkey.
Acute myeloid leukemia (AML) was first categorized in 1976 by French, American and British researchers, and divided into eight subgroups (M0 to M7), depending on the cytochemical or histological changes in the leukemic cells. The gene mutations of , and are the most common that cooperate together in the prognosis of AML. The gene that is a hematopoietic transcription factor, is located on chromosome 19q13.
View Article and Find Full Text PDFInt J Mol Sci
January 2021
Unit of Cell Biology, GIGA-Neurosciences, CHU Sart-Tilman, University of Liège, B36, 4000 Liège, Belgium.
Unlike in most eukaryotic cells, the genetic information of budding yeast in the exponential growth phase is only present in the form of decondensed chromatin, a configuration that does not allow its visualization in cell nuclei conventionally prepared for transmission electron microscopy. In this work, we studied the distribution of chromatin and its relationships to the nucleolus using different cytochemical and immunocytological approaches applied to yeast cells subjected to hyperosmotic shock. Our results show that osmotic shock induces the formation of heterochromatin patches in the nucleoplasm and intranucleolar regions of the yeast nucleus.
View Article and Find Full Text PDFJ Obstet Gynaecol
April 2021
Research, and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Diabetes Mellitus (DM) is the most common endocrine disorder affecting many human physiological systems and tissues, including the reproductive organs in men. The age of individuals suffering from this disease has been falling rapidly in recent years. This study compared the effect of DM on sperm parameters, chromatin quality, and apoptosis, as well as the expression profile of protamine genes in men with and without DM using molecular and cytochemical assays.
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