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Establishment and perturbation of human gut microbiome: common trends and variations between Indian and global populations.
Gut Microbiome (Camb)
June 2024
Department of Systems and Computational Biology, University of Hyderabad, Hyderabad, India.
Human gut microbial species are crucial for dietary metabolism and biosynthesis of micronutrients. Digested products are utilised by the host as well as several gut bacterial species. These species are influenced by various factors such as diet, age, geographical location, and ethnicity.
View Article and Find Full Text PDFAmoebae: beyond pathogens- exploring their benefits and future potential.
Front Cell Infect Microbiol
January 2025
Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational and Research Institute (RKMVERI), Kolkata, India.
Amoebae, fascinatingly diverse protists, showcase a dual nature that positions them as both friends and foes in our world. These organisms, defined by their distinctive pseudopodia, span a spectrum from harmful to helpful. On the darker side, species like pose serious health risks, causing intestinal and liver diseases, while the infamous "brain-eating" leads to fatal primary amoebic meningoencephalitis (PAM), with a daunting 97% mortality rate.
View Article and Find Full Text PDFTranscriptomic profiling of "brain-eating amoeba" infection in mice: the host and the protozoa perspectives.
Front Cell Infect Microbiol
December 2024
Institut Pasteur de la Guadeloupe, Les Abymes, Guadeloupe, France.
The free-living amoeba (NF) causes a rare but lethal parasitic meningoencephalitis (PAM) in humans. Currently, this disease lacks effective treatments and the specific molecular mechanisms that govern NF pathogenesis and host brain response remain unknown. To address some of these issues, we sought to explore naturally existing virulence diversity within environmental NF isolates.
View Article and Find Full Text PDFEnlightening the promising role of nanoparticle-based treatments against Naegleria fowleri-induced primary amoebic meningoencephalitis: A brain-eating disease.
Microb Pathog
February 2025
Diamond Harbour Women's University, Department of Zoology, Sarisha, West Bengal, 743368, India. Electronic address:
Naegleria fowleri, is the causative agent of Primary Amoebic Meningoencephalitis (PAM), a lethal acute brain inflammation with high mortality. The virulent and reproductively active trophozoite stage of N. fowleri migrates to central nervous system (CNS) by entering through nasal passage and causes severe neural infection, brain disease and inflammation with high mortality.
View Article and Find Full Text PDF[Balamuthia mandrillaris amebic encephalitis: report of a case].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, Affiliated Hospital of Hebei University, Baoding071000, China.
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