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Simultaneous determination of three β-Lactam/β-lactamase inhibitor combinations in critically ill patients by UPLC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China. Electronic address:
β-Lactam/β-lactamase inhibitors (BL/BLIs) are widely used in critically ill patients. Recent research has shown the importance of therapeutic drug monitoring (TDM) of BLs, but few studies have highlighted the importance of detecting BLIs in critically ill patients. In our laboratory, we have developed and validated a simple and robust method for the determination of ceftazidime, cefoperazone, piperacillin, avibactam, sulbactam and tazobactam in human plasma by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
View Article and Find Full Text PDFRapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation.
bioRxiv
December 2024
Stanford Blood Center, Stanford Health Care, Stanford, California, USA.
Background And Objectives: Apheresis platelets products and plasma are essential for medical interventions, but both still have inherent risks associated with contamination and viral transmission. Platelet products are vulnerable to bacterial contamination due to storage conditions, while plasma requires extensive screening to minimize virus transmission risks. Here we investigate rapid irradiation to sterilizing doses for bacteria and viruses as an innovative pathogen reduction technology.
View Article and Find Full Text PDFHyaluronic acid coating of poly(β-amino ester)/mRNA polyplexes enables ultra-high transfection efficiency.
J Control Release
December 2024
School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address:
Article Synopsis
- mRNA is crucial for various biomedical applications, but safe and efficient delivery into target cells is key for its effectiveness.
- A new ternary delivery system was developed using linear poly(β-amino ester)s (LPAEs) coated with hyaluronic acid (HA), which significantly improves mRNA transfection efficiency and cell viability.
- The HA coating enhances the properties of the polyplexes, increasing their ability to interact with cell membranes, suggesting this method could benefit other non-viral mRNA delivery systems.
FLASH Radiotherapy: Benefits, Mechanisms, and Obstacles to Its Clinical Application.
Int J Mol Sci
November 2024
Moscow Center for Advanced Studies, Kulakova Str. 20, Moscow 123592, Russia.
Radiotherapy (RT) has been shown to be a cornerstone of both palliative and curative tumor care. RT has generally been reported to be sharply limited by ionizing radiation (IR)-induced toxicity, thereby constraining the control effect of RT on tumor growth. FLASH-RT is the delivery of ultra-high dose rate (UHDR) several orders of magnitude higher than what is presently used in conventional RT (CONV-RT).
View Article and Find Full Text PDFThe Neutron Absorption Capacity of a Composite Material Based on Ultrahigh Molecular Weight Polyethylene Under Reactor Radiation Conditions.
Polymers (Basel)
December 2024
Institute of Atomic Energy NNC RK, Kurchatov 140000, Kazakhstan.
This work presents the results of a study on the influence of fillers on the neutron absorption capacity of materials made from ultra-high molecular weight polyethylene (UHMWPE). Composite materials based on UHMWPE were obtained using gas-flame technology with the addition of powdered UHMWPE fillers (HBO, WC, and PbO). A radiation cassette has been developed and constructed for conducting studies on the neutron absorption capacity of the material, allowing for the placement of a sample with activation indicators.
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