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Resilience Unveiled: Myxedema Coma in a Hostage Survivor.

Isr Med Assoc J

November 2024

Department of Emergency Medicine, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.

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Myxedema Coma-associated Pancytopenia: A Case Report.

Rambam Maimonides Med J

October 2024

Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Article Synopsis
  • Pancytopenia is a condition characterized by low levels of red and white blood cells as well as platelets, and diagnosing it can be complex due to various potential causes.
  • The text discusses a rare case of a 53-year-old man experiencing myxedema coma, a severe form of untreated hypothyroidism, which led to his pancytopenia symptoms, including confusion and unstable vital signs.
  • The patient was treated with intravenous levothyroxine and other supportive measures, resulting in improved health and normalized blood counts, highlighting the importance of recognizing myxedema coma in older patients who may not have regular healthcare access.
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Article Synopsis
  • Myxedema coma often involves reduced consciousness and low body temperature, potentially linked to thyroid issues, especially in patients with head trauma and central hormone deficiencies.
  • A 52-year-old man with head trauma exhibited symptoms like drowsiness and hypotension, with initial tests showing normal TSH levels but low ACTH and FT4, and his condition worsened before improving with medication.
  • The case highlights the importance of assessing both TSH and FT4 levels for diagnosing central hypothyroidism, as relying solely on TSH might lead to overlooked conditions in patients showing hormone deficiency symptoms post-trauma.
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Article Synopsis
  • Myxedema coma is a severe and rare complication of hypothyroidism resulting in various body system failures, including neuropsychiatric and cardiovascular issues.
  • From 2010 to 2022, our hospital treated three cases of myxedema coma, which showed similar characteristics to past reports, but all were negative for thyroid autoantibodies, with one case revealing end-stage thyroiditis during autopsy.
  • A review of cases from 1999 to 2022 indicated that many instances of myxedema coma were linked to seronegative primary hypothyroidism, particularly notable in Japan.
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