The antibiotic efrotomycin (I), C59H88N2O20, was isolated from cultures of Nocardia lactamdurans as an amorphous yellow powder. Mass spectral and NMR analyses show that the compound is a glycoside of the known antibiotic aurodox (II), C44H62N2O12. Ozonolysis and hydrolysis of I produced the disaccharide V, 6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-alpha -L-mannopyranosyl)-3-O-methyl-beta-D-allopyranose. This disaccharide is attached to the 4-hydroxyl group of the hexahydropyran substructure of aurodox via a beta-linkage to C-1 of the allose.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.7164/antibiotics.38.1691 | DOI Listing |
Publication Analysis
Top Keywords
structure efrotomycin
4
efrotomycin antibiotic
4
antibiotic efrotomycin
4
efrotomycin c59h88n2o20
4
c59h88n2o20 isolated
4
isolated cultures
4
cultures nocardia
4
nocardia lactamdurans
4
lactamdurans amorphous
4
amorphous yellow
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!