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Introduction: Forty-five percent of Alzheimer's disease (AD) cases may have been preventable through protective factors. Reserve, resilience, and resistance share common neurocognitive adaptive processes, acting through protective mechanisms. In this article we propose the development and validation of a new scale, called dynamic Neurocognitive Adaptation, developed in this direction.
View Article and Find Full Text PDFDynamics of fungal endophytic communities in bilberry (Vaccinium myrtillus L.) fruits through development is shaped by host phenolic compounds.
FEMS Microbiol Ecol
January 2025
Ecology and Genetics Research Unit, PO Box 3000, University of Oulu, FI-90014 Oulu, Finland.
The physical and chemical properties of wild berry fruits change dramatically during development, and the ripe berries host species-specific endophytic communities. However, the development of fungal endophytic communities during berry ripening is unknown. We studied bilberries (Vaccinium myrtillus L.
View Article and Find Full Text PDFAttention to social threat predicts diurnal cortisol dynamics during the high school transition.
Psychoneuroendocrinology
January 2025
Department of Psychology, University of British Columbia, Vancouver, BC, Canada.
Adolescence is a developmental period marked by significant social shifts accompanied by concurrent changes across biological, cognitive, and emotional domains. Within adolescence, the high school transition is a pivotal time for youth that is ripe with opportunities yet has the potential to disrupt functioning. An increasingly sophisticated understanding of health and developmental biology indicates that the hypothalamic-pituitary-adrenal (HPA) axis plays an important role in transducing social experiences into physiological changes that have long-term impacts on health and wellbeing.
View Article and Find Full Text PDFClinical, Radiological Features and Treatment Outcomes of Tuberculosis in Patients Aged 75 Years and Older.
J Epidemiol Glob Health
December 2024
Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Introduction: Tuberculosis (TB) is a significant contributor to morbidity and mortality. With a progressively aging population, TB is increasingly encountered in older adults. Understanding the clinical presentation and optimal treatment strategies for TB in this population is essential.
View Article and Find Full Text PDFA clinician's guide to effects of obesity on childhood asthma and into adulthood.
Expert Rev Respir Med
October 2024
Division of Respiratory and Sleep Medicine, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Introduction: Obesity, one of the most common chronic conditions affecting the human race globally, affects several organ systems, including the respiratory system, where it contributes to onset and high burden of asthma. Childhood onset of obesity-related asthma is associated with high persistent morbidity into adulthood.
Areas Covered: In this review, we discuss the disease burden in children and adults to highlight the overlap between symptoms and pulmonary function deficits associated with obesity-related asthma in both age ranges, and then discuss the potential role of three distinct mechanisms, that of mechanical fat load, immune perturbations, and of metabolic perturbations on the disease burden.
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