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[Genomic characterization of head and neck squamous cell carcinoma: Impact and challenges for therapeutic management].
Bull Cancer
September 2018
Centre François-Baclesse, département de radiothérapie, 3, avenue Général-Harris, 14076 Caen, France.
Squamous cell carcinomas are the most frequent subgroup among head and neck malignant tumors (HNSCC). Tobacco (±alcohol) and HPV infection, the two main risk factors, define two entities with distinct anatomo-clinical and genetic features. HPV-positive, non-tobacco-related HNSCCs are associated with a better prognosis, a rather simple genomic profile, frequent activating mutations of genes involved in pi3kinase-pathway, and the scarcity of mutations of tumor suppressor genes.
View Article and Find Full Text PDFAnatomo-clinical correlations in hepatic steatosis in patients with C chronic hepatitis.
Rom J Morphol Embryol
April 2017
Department of Cardiology, University of Medicine and Pharmacy of Craiova, Romania;
Hepatic steatosis is a progressive liver disease, frequently met in chronic virus C hepatitis, playing an important role in its evolution towards fibrosis, necroinflammation and the final stage the hepatocellular carcinoma. The present paper studies the correlation between clinico-epidemiological parameters and the pathology test outcome in patients with hepatic biopsies carried out before they began the antiviral treatment. We used the classical histological staining and the immunolabeling.
View Article and Find Full Text PDF[Cellular hemangioma of the parotid gland associated with an infection by cytomegalovirus].
Rev Stomatol Chir Maxillofac
October 2003
Laboratoire d'Anatomie et de Cytologie Pathologiques, CHU Habib Bourguiba, 3029 Sfax, Tunisie.
We report a case in a two and a half month old boy presenting a mass in the right parotid gland. Sonography showed a vascular tumor. Magnetic resonance imaging showed an expansive process of the parotid gland measuring 61 x 39 mm taking the contrast with hypo signal in T1 and hyper signal in T2-weighted images.
View Article and Find Full Text PDFDetection of genomic- and minus-strand of hepatitis C virus RNA in the liver of chronic hepatitis C patients by strand-specific semiquantitative reverse-transcriptase polymerase chain reaction.
Hepatology
February 1999
Divisions of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland.
Studies aimed at correlating the intrahepatic hepatitis C virus (HCV)-RNA level and anatomo-clinical features have been difficult because of sensitivity and specificity shortcomings of available techniques. We titered the genomic- and minus-strand HCV RNAs by a strand-specific, semiquantitative, genotype-independent reverse-transcriptase polymerase chain reaction (RT-PCR) in the liver tissue of 61 patients with chronic hepatitis C. Findings were correlated with the levels of HCV RNA in the serum, the HCV genotype, the expression of intrahepatic HCV antigens, the histological activity (using separate scores for the lobular and the portal/periportal necroinflammatory activity and for the fibrosis), and the response to interferon alfa (IFN-alpha) treatment.
View Article and Find Full Text PDFDetection of hepatitis C virus RNA in liver tissue: an overview.
Ital J Gastroenterol Hepatol
April 1998
Division of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland.
One of the approaches used to study the pathogenesis of hepatitis C virus-associated disease is to follow its replicative pattern in infected tissues and to establish anatomo-clinical correlations. As in other viral infections, the techniques used to study hepatitis C virus replication in tissues are the Northern gel analysis, the reverse transcription-polymerase chain reaction, the in situ hybridization and the in situ-polymerase chain reaction. The replicative level of hepatitis C virus is, however, low, and the results reported using the above techniques are often discordant and difficult to reproduce, suggesting that both sensitivity and specificity are major issues.
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