Sparteine oxidation was polymorphic among 301 healthy Danish volunteers. Hence 22 subjects or 7.3% were phenotyped as poor metabolizers (PM) whereas 279 subjects were classified as extensive metabolizers (EM). The metabolic ratio (MR) between sparteine and 2- and 5-dehydrosparteine (% of dose) in 12 hrs urine ranged from 0.11-12.6 in EM and from 30-394 in PM. Urinary excretion of 2- and 5-dehydrosparteine also discriminated between PM and EM. Age, sex, and smoking habits did not influence the MR. This study confirms that sparteine is a useful probe drug in pharmacogenetic investigations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0773.1985.tb00058.x | DOI Listing |
Publication Analysis
Top Keywords
sparteine oxidation
8
sparteine
4
oxidation polymorphism
4
polymorphism denmark
4
denmark sparteine
4
oxidation polymorphic
4
polymorphic 301
4
301 healthy
4
healthy danish
4
danish volunteers
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!