Unspecific interaction was analyzed between native 125I-lipoproteins of low density (LDL) as well as 125I-LDL, maintained in rabbit circulation during 4 hrs, and fibroblasts and macrophages. Alterations in properties of the LDL, occurred in blood, were accompanied by an increase in their affinity towards macrophages and a decrease in the affinity to fibroblasts. In vivo effect of HDL on catabolism of LDL was manifested as inhibition of extracellular modification of LDL and elimination of them from circulation, and in vitro--as inhibition of the native LDL capture by fibroblasts and, especially, by macrophages. In vivo inhibitory effect of HDL on modification of LDL, which are captured by cells (including arterial endothelial cells) by means of unspecific endocytosis, appears to be one of mechanisms in the antiatherogenic action of HDL.
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