The clinicofunctional characteristics of the kidneys were estimated, biopsy of the kidney and skin with an immunohistochemical study was performed and some immunity values considered in 17 patients with type I diabetes mellitus. The study was performed with respect to the degree of expression of the clinical signs of nephropathy including the preclinical stage, too. Three types of morphological changes in the kidney and skin were singled out. Initial tubuloglomerular disorders occurred at the preclinical stage of nephroangiopathy. The nature of changes in the skin coincided mostly with changes in the kidney lagging behind in some cases. The results confirmed the leading role of metabolic derangements in the genesis of microangiopathies and a necessity of a good compensation of diabetes for its prevention. The immunohistochemical and immunological findings did not make it possible to exclude the immune mechanisms in the development of diabetic nephroangiopathy.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Metabolic, hemodynamic, blood rheological, hormonal, immune, age- and other related mechanisms are involved in the development of nephroangiopathy in types 1 and 2 diabetes mellitus. The initial increase in glomerular filtration rapidly gives way to progressive sclerosis and hyalinosis of glomeruli and afferent and efferent arterioles. These changes can be arrested only in early stages of diabetic nephroangiopathy.
View Article and Find Full Text PDFEffect of 9-12 month treatment with captopril on dopplerographic parameters of intrarenal blood flow and renal function was studied in 30 hypertensive diabetics without clinical signs of nephroangiopathy. There was an interrelationship between strict blood pressure (BP) control (average 24-hour BP below 135/83) and improvement of parameters of intrarenal hemodynamics. BP normalization and most pronounced positive changes of renal perfusion during therapy with captopril were achieved in patients with mild hypertension and initially high intrarenal resistance yet at the stage of normo- or microalbuminuria.
View Article and Find Full Text PDFTo evaluate the secretion of vasoactive factors in vascular endothelium of patients with non-insulin-dependent diabetes mellitus (NIDDM) the authors examined 31 NIDDM patients. Of them, 18 had no signs of renal involvement, 13 patients showed apparent diabetic nephropathy (DN). In the former patients the blood contained much greater content of vasodilating factor prostacyclin than of vasoconstricting factor endothelin-1 (ET-1) and thromboxan A2 (TxA2).
View Article and Find Full Text PDFHemodynamic changes of lesser circulation were investigated in 108 patients with diabetic nephroangiopathy. They were also given vitamin E therapy (8 micrograms/kg of body mass) for 2 weeks to correct metabolic derangements and indices of pulmonary hemodynamics. Partial renal function was determined with 131I-hippuran and 99mTc-DTPA renoscintigraphy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!