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Hypothalamic-pituitary-adrenal axis in anorexia nervosa; an underestimated endocrine dysfunction among adolescents.
Front Pediatr
December 2024
Pediatric Department, Buzzi Children's Hospital, Milan, Italy.
In patients affected by anorexia nervosa (AN) different endocrine abnormalities have been described, but, among them, hypothalamic-pituitary-adrenal (HPA) dysfunction, although associated to important side effects, is underestimated and has no therapeutical options. We present a narrative literature review to investigate the HPA axis in patients with AN, in order to highlight HPA dysfunction and its effects. We also described the crucial role of HPA monitoring, and to consider eventual therapeutic and preventive strategies in AN patients.
View Article and Find Full Text PDFInnovative Approaches to Digital Health in Ovulation Detection: A Review of Current Methods and Emerging Technologies.
Semin Reprod Med
June 2024
Quanovate Tech, San Francisco, California.
Ovulation is a vital sign, as significant as body temperature, heart rate, respiratory rate, and blood pressure, in assessing overall health and identifying potential health issues. Ovulation is a key event of the menstrual cycle that provides insights into the hormonal and reproductive health aspects. Affected by the orchestra of hormones, namely thyroid, prolactin, and androgens, disruptions in ovulation can indicate endocrinological conditions and lead to gynecological problems, such as heavy menstrual bleeding, irregular periods, amenorrhea, dysmenorrhea, and difficulties in getting pregnant.
View Article and Find Full Text PDFPediatric Suprasellar Tumors: Unveiling the Mysteries of Craniopharyngioma and Germ Cell Tumors-Insights From Diagnosis to Advanced Therapeutics.
Pediatr Neurol
January 2025
The Division of Hematology and Oncology, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Background: Pediatric suprasellar tumors represent a unique and intricate challenge in the landscape of pediatric neuro-oncology.
Methods: We conducted an in-depth literature review, focusing on large clinical trials and major publications in pediatric suprasellar tumors, particularly craniopharyngiomas and germ cell tumors, to provide a comprehensive perspective on the challenges in the diagnosis, treatment, and molecular aspects of these tumors.
Results: Nestled within the critical confines of the suprasellar region, these tumors manifest against the backdrop of crucial growth and developmental processes.
Endocrine disorders in Rett syndrome: a systematic review of the literature.
Front Endocrinol (Lausanne)
November 2024
Unit of Pediatrics, Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
Background: Rett syndrome (RTT) is an X-linked progressive neurodevelopmental disorder that involves mainly girls and is the second most frequent cause of genetic intellectual disability. RTT leads to neurological regression between 6 and 18 months of life and could be associated with a variable neurological impairment. However, RTT affects not only neurological function but also wide aspects of non-neurological organs.
View Article and Find Full Text PDFHypospadias Associated With Fetal Growth Restriction: A Multicentric Descriptive and Prognostic Cohort Study.
Prenat Diagn
December 2024
Department of Obstetrics and Gynecology, AP-HP, Port-Royal Maternity, Université Paris Cité, Paris, France.
Objective: To determine the prevalence of genetic and endocrine abnormalities and to assess fetal, neonatal and surgical outcomes in cases of hypospadias associated with fetal growth restriction.
Method: A multicentric retrospective study was conducted across five prenatal diagnosis centers in Paris. The cohort encompassed all fetuses diagnosed with the combination of fetal growth restriction < 10th percentile (FGR) and hypospadias from 2013 to 2021.
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