Left ventricular thrombi were detected in 98 (11%) of 864 consecutive patients examined by 2-D-echocardiography in the chronic phase of myocardial infarction. Using unequivocal criteria in identifying intracavitary masses as thrombus, the sensitivity and specificity of the echocardiographic diagnosis reached 90% compared to intraoperative findings (n = 23). To avoid false positive diagnoses, normal apical structures like muscular trabeculae must be ruled out, preferably by applying high-frequency transducers. All thrombi were located on akinetic or dyskinetic segments near the ventricular apex. Accordingly they were best visualised in the apical 4-chamber (92%) and 2-chamber (96%) views as well as in apical short-axis cross-sections (49%). Thrombus size ranged from 0.5 to 32 cm2. Two-thirds of the thrombi appeared as flat, one-third as protruding masses. Thrombi were found mainly with anterior wall infarctions (14.5%) and with aneurysms (28.5%), but rarely with posterior wall infarctions (.6%). 95% of the thrombus patients had suffered large infarctions. The rate of embolic events prior to the thrombus diagnosis was 7% in patients with thrombi but only 0.6% in patients without thrombi.
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http://dx.doi.org/10.1055/s-2007-1006074 | DOI Listing |
Eur Stroke J
January 2025
Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Background: Severe left ventricular (LV) systolic dysfunction (ejection fraction [EF] < 30%) is a known cardiovascular risk factor and a major cause of cardioembolism. However, less severe forms of LV disease (LVD), such as mild-to-moderate LV dysfunction and LV wall motion abnormalities (LVWMAs), are considered potential minor cardiac sources in Embolic Stroke of Undetermined Source (ESUS), but their role is underexplored. This study aims to evaluate the prevalence of LVD in ESUS and its association with adverse vascular events and mortality.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
College of Public Health, University of Kentucky, Lexington, KY, USA.
Background: Brain arteriolosclerosis (B-ASC) is a pathologic hallmark characterized by dysmorphic brain arteriolar wall thickening. B-ASC is a common finding at autopsy in aged persons - some degree of B-ASC is seen in >80% of brains beyond age 80 years - and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC.
View Article and Find Full Text PDFFront Neurol
December 2024
Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Objective: To investigate the association between cerebral small vessel disease burden, along with its individual imaging features, as well as other imaging features and early neurological deterioration in isolated pontine infarction.
Methods: 107 patients with acute isolated pontine infarcts, within 24 h of symptom onset, were retrospectively analyzed. The mean age of the participants was 67 years.
J Cardiovasc Pharmacol
January 2025
School of Cardiovascular and Metabolic Medicine & Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Rev Esp Cardiol (Engl Ed)
December 2024
Center of Excellence of Cardiovascular Sciences, Ospedale Isola Tiberina - Gemelli Isola, Catholic University of the Sacred Heart, Rome, Italy.
Unlabelled: Introduction y objectives: Tako-tsubo syndrome (TTS) is a cardiac condition that mimics acute coronary syndrome, characterized by transient left ventricular dysfunction in the absence of culprit coronary artery stenosis. Although its etiology remains unknown, reversible microvascular dysfunction secondary to an adrenergic surge is thought to play a role. Treatment is empirical, although most patients receive beta-blockers (BB) in clinical practice.
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