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Chemical composition and insecticidal efficacy of two animals' horn and hoof crude extracts against lesser grains borer, (F.) [Coleoptera: Bostrichidae].
Heliyon
January 2025
Department of Animal Production and Health, School of Agriculture and Agricultural Technology, Federal University of Technology,P. M. B. 704, Akure, Ondo State, Nigeria.
This research evaluated the profiling of bioactive compounds and insecticidal activities of the crude extracts of horns and hoofs of cow and goat against on wheat grains. Different concentrations (0.1, 0.
View Article and Find Full Text PDFMetabolomics-based treatment for chronic diseases: results from a multidisciplinary clinical study.
BMJ Nutr Prev Health
December 2024
Laboratory of Toxicology and Forensic Sciences, Medical School of the University of Crete, Crete, Greece.
Background: Non-communicable diseases (NCDs), known as chronic diseases, significantly impact patients' quality of life (QoL) and increase medical expenses. The majority of risk factors are modifiable, and metabolomics has been suggested as a promising strategy for their evaluation, though real-world data are scarce. This study evaluated the QoL improvement and cost-effectiveness of a metabolomics-based treatment for NCDs, aiming to restore metabolic dysfunctions and nutritional deficiencies.
View Article and Find Full Text PDFCaspase-1 activation, IL-1/IL-6 signature and IFNγ-induced chemokines in lungs of COVID-19 patients.
Front Immunol
January 2025
Aix-Marseille Université, INSERM, INRAE, C2VN, Marseille, France.
Rationale: COVID-19-associated acute-respiratory distress syndrome (C-ARDS) results from a direct viral injury associated with host excessive innate immune response mainly affecting the lungs. However, cytokine profile in the lung compartment of C-ARDS patients has not been widely studied, nor compared to non-COVID related ARDS (NC-ARDS).
Objectives: To evaluate caspase-1 activation, IL-1 signature, and other inflammatory cytokine pathways associated with tissue damage using post-mortem lung tissues, bronchoalveolar lavage fluids (BALF), and serum across the spectrum of COVID-19 severity.
Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications.
Clin Epidemiol
January 2025
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Objective: Patients who undergo major lower extremity amputation (MLEA) have the highest postoperative mortality among orthopedic patient groups. The comorbidity profile for MLEA patients is often extensive and associated with elevated postoperative mortality. This study primarily aimed to investigate the increased short- and long-term mortality following first and subsequent major lower extremity amputation.
View Article and Find Full Text PDFAnamnesis Checklist for Informed Oral Contraceptive Choices: A Spanish Perspective.
Womens Health Rep (New Rochelle)
January 2025
Hospital Nuestra Señora de Fátima, Vithas Vigo, Vigo, Spain.
Objectives: This study aimed to develop an anamnesis checklist for oral contraceptive (OC) choice focused on their safety profile and associated risk factors.
Study Design: This study involved eight health care professionals in Spain, including six gynecologists and two internists, selected for their expertise in contraception counseling. We employed the design-thinking process, structured in five phases: empathizing with patients' needs, defining key areas of impact, devising innovative solutions, prototyping ideas into testable proposals, and validating prototypes.
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