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Enhancement of Transdermal Drug Delivery: Integrating Microneedles with Biodegradable Microparticles.
Mol Pharm
January 2025
Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, Georgia 30341, United States.
This investigation aimed to enhance transdermal methotrexate delivery through human skin by employing Dr. Pen microneedles and poly(d,l-lactide--glycolide) acid microparticles formulated from eight polymer grades (Expansorb DLG 95-4A, DLG 75-5A, DLG 50-2A, DLG 50-5A, DLG 50-8A, DLG 50-6P, DLG 50-7P, and DLL 10-15A). A comprehensive characterization of the microparticles was performed, encompassing various parameters such as size, charge, morphology, microencapsulation efficiency, yield, release kinetics, and chemical composition.
View Article and Find Full Text PDFRefractory lipoatrophy treated with autologous whole blood injection: A case report.
World J Clin Cases
January 2025
Department of Dermatology, College of Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, South Korea.
Background: Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy, alopecia, hypopigmentation, and hyperpigmentation. Although cutaneous atrophy can spontaneously resolve, several treatment options have been suggested for this condition.
Case Summary: In this paper, we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood (AWB) injection, as the condition had been unresponsive to fractional laser therapy.
Clinical efficacy of CO laser combined with 5-aminolevulinic acid photodynamic therapy in treating periungual and plantar warts.
Am J Transl Res
December 2024
Department of Dermatology, Qingpu Branch of Zhongshan Hospital, Fudan University Shanghai, China.
Objective: To analyze the clinical application value of CO laser combined with 5-aminolevulinic acid photodynamic therapy for periungual and plantar warts.
Methods: Data from patients with periungual and plantar warts treated at Qingpu branch of Zhongshan Hospital, Fudan University between August 2022 and January 2024 were retrospectively analyzed. After screening based on inclusion and exclusion criteria, 96 patients were included and categorized into two groups according to their treatment regimens: a combination group (n=50, receiving CO laser therapy and 5-aminolevulinic acid photodynamic therapy) and a control group (n=46, undergoing CO laser treatment alone).
Changes in the effective optical zone following hyperopic keratorefractive lenticule extraction.
Ann Med
December 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Objective: To evaluate the longitudinal changes in the effective optical zone (EOZ) following hyperopic keratorefractive lenticule extraction (KLEx) and investigate factors influencing the EOZ.
Patients And Methods: This retrospective study included 27 patients who underwent hyperopic KLEx. According to the transition zone (TZ) sizes, they were divided into two groups: group A (21 eyes) with a 2.
Extracellular vesicles of Candida albicans show dual effects on Enterococcus faecalis growth and virulence: A laboratory-based investigation.
Int Endod J
January 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Aim: Previous studies have shown the important relationships between Enterococcus faecalis and Candida albicans in post-treatment endodontic disease (PTED). However, the fungal-bacterial interactions and their possible functional routes are less understood. In this study, we investigated the effect of extracellular vesicles (EVs) derived from C.
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