A newborn boy, whose mother had suffered from varicella in her 15th week of gestation, showed at birth fresh skin ulcers and cicatricial skin lesions on the right side of his face. Ocular abnormalities (chorioretinitis) as well as persistent dysphagia were observed. Up to date, only 25 cases of congenital varicella have been reported. They frequently showed cutaneous scars in a segmental distribution, hypoplasia of the locomotor system and ocular defects. In view of the extreme rarity of this condition, we do not consider diagnostic and prophylactic measures compulsory in cases of varicella contact during pregnancy.
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Indian J Pediatr
January 2010
Department of Pediatrics, Government Medical College, Jammu, J & K State, India.
An 18 hour old female newborn born to a 3rd gravida HIV -ve mother, presented with a large erythematous patch of skin on right forehead and hazy right eye since birth. There was history of Chicken pox in mother during fourteenth week of pregnancy.
View Article and Find Full Text PDFJ Gynecol Obstet Biol Reprod (Paris)
July 1996
Service de Gynécologie-Obstétrique 1, Hôpital Cochin-Port-Royal, Paris.
The first case of prenatal diagnosis of congenital varicella by amniotic fluid viral culture and PCR is reported. Chickenpox is a benign disease in children, but it can lead to severe complications in the adult, especially in the pregnant woman. Five percent of women in childbearing age are not immunised, and the incidence of gestational chickenpox is between 1 and 7 per 10,000.
View Article and Find Full Text PDFSemin Pediatr Neurol
September 1994
Department of Pediatrics, University of Iowa College of Medicine, Iowa City, USA.
Congenital infections are caused by both varicella-zoster virus (VZV) and herpes simplex virus type 2 (HSV-2). The VZV fetopathy and the HSV fetopathy exhibit several similarities. Both affect the skin, eyes and brain, often with devastating consequences.
View Article and Find Full Text PDFMol Biol Med
October 1989
Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242.
Varicella-zoster virus (VZV) is one of the six human herpesviruses. The viral genome encodes five glycoproteins among its 70 open reading frames; these have been designated gpI to gpV. VZV causes the primary disease chickenpox, usually in children, after which the virus remains latent in the dorsal root ganglia.
View Article and Find Full Text PDFA newborn boy, whose mother had suffered from varicella in her 15th week of gestation, showed at birth fresh skin ulcers and cicatricial skin lesions on the right side of his face. Ocular abnormalities (chorioretinitis) as well as persistent dysphagia were observed. Up to date, only 25 cases of congenital varicella have been reported.
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