The disseminated forms of skin tuberculosis are extremely uncommon and can occur as acute miliary tuberculosis with skin involvement, which is a severe disease with a rapid course, or as slowly developing lupus vulgaris, i.e., "postexanthematic lupus vulgaris" or "lupus vulgaris disseminatus". A 61-year-old female patient developed unusual lichenoid brownish lesions caused by disseminated lupus vulgaris, which were confined to the right leg. The patient had no other signs of tuberculosis.
Download full-text PDF |
Source |
---|
Nat Genet
January 2025
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus.
View Article and Find Full Text PDFBMJ Case Rep
December 2024
Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Antibiotics are indicated for inappropriately prolonged durations not only for infectious diseases but also for non-infectious dermatologic conditions such as acne vulgaris, but inappropriate use is not uncommon. Inappropriate antibiotic prescription can contribute to the emergence of multidrug-resistant organisms, patient harm such as adverse drug events and increased healthcare costs. We experienced a case involving a late adolescent with acne vulgaris who had been treated with minocycline for more than 2 years, leading to the development of drug-induced lupus, attributed to minocycline.
View Article and Find Full Text PDFAutoimmun Rev
December 2024
Reichman University, Herzelia, Israel; Zabludowicz Center for Autoimmune Diseases (Founder), Sheba Medical Center, Tel-Hashomer, Israel.
Background: Low vitamin D levels are commonly observed in autoimmune diseases, suggesting a potential role in disease pathogenesis. The presence of anti-vitamin D antibodies may contribute to these deficiencies and influence autoimmune processes.
Objective: To review and analyze studies investigating the occurrence of anti-vitamin D antibodies in autoimmune diseases.
Am J Med
November 2024
Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Mibu, Tochigi, Japan.
Ann Dermatol Venereol
December 2024
Infectious and Tropical Diseases Department, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, AP-HP, Paris, France; Sorbonne University, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
Objectives: Cutaneous tuberculosis (CTB) may be over-diagnosed due to imprecise diagnostic criteria or overlooked where mycobacterial investigations are negative. We evaluated the distinction between multibacillary and paucibacillary forms of CTB, as well as drug resistance and cure rates according to the results of mycobacterial investigations.
Methods: We included retrospectively all patients diagnosed with CTB from 1995 to 2018 in two hospitals in Paris.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!