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Toluene-2,5-Diamine Sulfate: Allergen of the Year 2025.
Dermatitis
January 2025
Department of Dermatology, University of California, San Francisco, California, USA.
Toluene-2,5-diamine sulfate (PTDS), also known as toluene diamine sulfate or 2,5-diaminotoluene sulfate, is an aromatic amine that can be used as a paraphenylenediamine (PPD) hair dye alternative. Patients may develop contact allergy to PTDS, and it is often omitted from standard patch test screening series, possibly leading to underdiagnosis. The American Contact Dermatitis Society named PTDS the Allergen of the Year for 2025, aiming to raise awareness of its dual role as both an allergen and an alternative for some PPD-allergic individuals.
View Article and Find Full Text PDFBerberrubine protects against cisplatin-induced ototoxicity by promoting folate biosynthesis.
Front Pharmacol
January 2025
Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Objective: This research investigated the possible shielding properties of BB (Berberrubine) against the harmful auditory effects of cisplatin, preliminarily delving into the underlying mechanisms responsible for this protection.
Methods: HEI-OC1 cell viability was determined using a Cell Counting Kit-8 (CCK-8). The impact of BB on cochlear hair cells was studied through cochlear explants culture.
MALDI-MSI: A potential game changer in forensic sciences.
Forensic Sci Med Pathol
January 2025
School of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan.
Matrix-assisted laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI) is an analytical technique used for the spatial mapping of drugs, explosives, and organic samples, making it a game-changer in Forensic examination. It detects a wide range of biomolecules in their native state without specific tags, antibodies, labels, and dyes. This review aims to highlight the advancement of MALDI-MSI over time and its impact on Forensic Science due to high-resolution molecular imaging.
View Article and Find Full Text PDFLeveraging an Innovative Green Copper and Nitrogen-Doped Carbon Quantum Dots for Quantification of Malathion in Various Matrices.
J Fluoresc
January 2025
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, 71524, Egypt.
Article Synopsis
- Carbon quantum dots (CQDs) are gaining attention as cost-effective and eco-friendly fluorescence probes, offering advantages over traditional luminescent techniques.
- A new type of copper and nitrogen-doped CQDs (Cu-N@CQDs) was created, achieving a high quantum yield of 40.20% for detecting malathion, an insecticide.
- The study demonstrated that the fluorescence intensity of Cu-N@CQDs decreased in response to malathion, allowing for accurate measurements across various samples like water and food, achieving high recovery rates.
Quantification of Lawsone and p-Phenylenediamine in Natural Henna Products for Hair Colouring Available in Poland.
Contact Dermatitis
January 2025
Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland.
Background: Henna is a powdered plant material traditionally used for medicinal and cosmetic purposes in Asia and the Mediterranean region. In North America and Europe, however, it is only used to colour the hair and decorate the body. This colouring process is due to the action of the secondary metabolite lawsone, which enables henna to produce orange to red shades of colour.
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