AI Article Synopsis
- The addition of interferon, either exogenous or from an inducer complex, to ineffective rabies vaccines significantly lowered mortality rates in mice exposed to the virus.
- A similar effect was observed in rhesus monkeys, but effective treatment required administration within 6 hours post-exposure.
- The rapid administration was crucial due to the high viral load the monkeys faced, which required prompt intervention for similar outcomes as seen in mice.
Article Abstract
Addition of interferon to ineffective rabies virus vaccines by the local injection of either exogenous interferon or a potent interferon inducer (a complex of polyriboinosinic-polyribocytidylic acid containing poly-L-lysine and carboxymethylcellulose) into the footpads of mice previously challenged with rabies virus dramatically reduced the mortality rate. A significant reduction in mortality rate was also noted when the interferon system was administered to rhesus monkeys, but only when treatment was given 6 hr after challenge with rabies virus. Since the monkeys were given an overwhelming challenge of virus, the treatment had to be given quickly to obtain results comparable to those in mice.
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| http://dx.doi.org/10.1093/infdis/136.2.286 | DOI Listing |
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