AI Article Synopsis
- The study examined how purine metabolism is affected in the skeletal muscles of 129 Re mice with hereditary muscular dystrophy, finding lower ATP levels and higher levels of AMP, IMP, and uric acid.
- There were no significant changes in the purine nucleotide pool in red blood cells, but physical properties of these cells showed reduced pliability and altered temperature resistance at 50 degrees Celsius.
- The observed changes in the erythrocytes' physical properties are linked to issues in the contractile structure beneath their membranes, suggesting a connection to the muscular dystrophy condition.
Article Abstract
The authors studied the metabolism of purine compounds in the skeletal muscle of 129 Re mice with hereditary muscular dystrophy (MD). The study showed impairment of purine metabolism which was expressed in a sharp decrease in ATP levels and an increase in the content of AMP, IMP and uric acid. No changes were revealed in the pool of purine nucleotides in murine red blood cells. A study of some physical properties of the red blood cells in mice with myopathy showed no alterations in the osmotic resistance of erythrocytes, yet there was a reduction in their pliability as compared to control. Examination of the temperature resistance revealed anomalies of red blood cells in myodystrophic mice at 50 degrees C. The detected changes of some physical properties of erythrocytes seem to be related to abnormalities of the sumbembranous contractile apparatus of these cells.
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