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The Role of Empiric Antifungal Therapy in Patients With Perforated Peptic Ulcer: An Updated Systematic Review and Meta-Analysis.
Am Surg
January 2025
Department of Surgery, Division of Acute Care Surgery and Surgical Critical Care, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Fungal growth is common in intraoperative cultures of patients with perforated peptic ulcer (PPU) leading to the common use of empiric antifungal therapy, with current evidence not clearly supporting this practice. The goal of this updated systematic review and meta-analysis was to synthesize the effect of empiric antifungals in patients with PPU. Eligible studies were identified through a comprehensive literature search in the MEDLINE (PubMed) and EMBASE databases, following the PRISMA 2020 statement.
View Article and Find Full Text PDFPrevalence of infection in China from 2014-2023: A systematic review and meta-analysis.
World J Gastroenterol
November 2024
Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China.
Article Synopsis
- The text outlines that a specific bacterium is the main cause of gastritis, peptic ulcers, and gastric cancer, and is recognized as a group 1 carcinogen by the World Health Organization, particularly impacting public health in China.* -
- A systematic review and meta-analysis were conducted, involving 152 studies and over 763,000 individuals, revealing an overall infection rate of 42.8% in mainland China, with the highest rates found in Northwest China and specific regions like Qinghai Province.* -
- The study indicated that while the infection prevalence has decreased in recent years, it remains notable among the elderly compared to children, highlighting the need for targeted prevention strategies in public health policies.*
Biogenic Nanoparticles as Safer Alternatives for Gastric Ulcers: An Update on Green Synthesis Methods, Toxicity, and Their Efficacy in Controlling Inflammation.
Biol Trace Elem Res
November 2024
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, 835215, India.
Peptic ulcers, affecting approximately 10% of the global population, can result from factors such as stress, alcohol use, smoking, NSAIDs, Helicobacter pylori infection, and genetic predisposition. Plant-based medicines are gaining recognition for their therapeutic potential, including in the treatment of peptic ulcers. Green chemistry methods for the biological synthesis of nanoparticles (NPs) provide a sustainable alternative to traditional chemical techniques.
View Article and Find Full Text PDFDumping syndrome: Update on pathophysiology, diagnosis, and management.
Neurogastroenterol Motil
November 2024
Translational Research Center for Gastrointestinal Diseases (TARGID), University of Leuven, Leuven, Belgium.
Background: Dumping syndrome is a complex of gastrointestinal symptoms originally studied in peptic ulcer surgery patients. At present, it is most prevalent in patients who underwent bariatric, upper gastrointestinal cancer or anti-reflux surgery. The symptom pattern comprises early and late dumping symptoms.
View Article and Find Full Text PDFClinical Implications of Proton Pump Inhibitors and Vonoprazan Micro/Nano Drug Delivery Systems for Gastric Acid-Related Disorders and Imaging.
Nanotheranostics
November 2024
Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi-221005, India.
Article Synopsis
- Gastric acid-related disorders like peptic ulcers and gastroesophageal reflux disease (GERD) are primarily caused by excessive stomach acid or bacterial infections, and can be treated with medications such as proton pump inhibitors (PPIs) and vonoprazan.
- While PPIs work by irreversibly blocking the proton pump in stomach cells, vonoprazan inhibits acid secretion by targeting the potassium-competitive acid blocker receptor, making it one of the most effective options for GERD.
- The review highlights various innovative micro/nano formulations of these medications, as well as the crucial role of imaging techniques like CT scans and endoscopy in diagnosing and managing these gastric acid disorders.
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