The analgetic effect of prolonged peridural analgesia with morphine was studied experimentally in rabbits. Increasing morphine dose did not noticeably enhance analgesia. Prolonged peridural analgesia with morphine was used to alleviate pain in 18 myocardial infarction patients. Morphine (2 mg) was introduced into the peridural space. The efficacy of the method is demonstrated.
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Exploration of the optimal programmed intermittent epidural bolus volume with the dural puncture epidural technique for labour analgesia: a biased-coin up-and-down sequential allocation study.
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