To specify indications for isovolumic hemodilution, hemostatic parameters (fibrinogen, soluble fibrin, fibrin decomposition products, platelet aggregation, thromboelastograms) were compared with clinical manifestations of coronary heart diseases (CHD) and coronarographic and bicycle-ergometric findings in 41 coronary patients. The increased blood viscosity syndrome was found in 63% of the patients. Isovolumic hemodilution was performed to control the detected disorders in 17 patients. Hemodilution was shown to be an effective means of controlling hemostatic disorders in coronary patients, hemostatic normalization being accompanied with clinical improvement in part of the cases.
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Bull Exp Biol Med
February 2024
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
We investigated the effect of a decrease in blood viscosity on the mean BP during isovolumic hemodilution and vasodilating activity of the endothelium in normotensive Wistar rats and spontaneously hypertensive rats (SHR). Blood viscosity was reduced by isovolumic hemodilution (replacement of 10% of circulating blood with an equal volume of plasma). Hemodilution caused the same reduction in blood viscosity by 16% in both groups of rats.
View Article and Find Full Text PDFAfr Health Sci
September 2023
Department of Anesthesiology, Emergency General Hospital, Beijing, China.
Background: To probe into the influences of different blood conservation techniques on the postoperative coagulation function and prognosis of elderly patients receiving Total Hip Arthroplasty (THA).
Methodology: A total of 60 patients were randomly divided into Autologous Blood Transfusion (ABT) group (n=30) and ANH group (n=30). For patients in the ABT group, an autologous blood recovery machine was used to recover, wash and filter the surgical field blood.
Ophthalmic Surg Lasers Imaging Retina
November 2023
Many interventions for nonarteritic central retinal artery occlusion (CRAO) are associated with serious complications and little effect on visual outcomes. We report on the findings of a Cochrane systematic review that searched seven databases for peer-reviewed articles reporting on treatments for acute nonarteritic CRAO. We assessed six randomized controlled trials, including interventions such as tissue plasminogen activator (t-PA), isovolumic hemodilution, eyeball massage, intraocular pressure reduction, anticoagulation, vasodilation, oxygen inhalation, laser embolysis, transcorneal electrical stimulation, thrombolysis, pentoxifylline, and enhanced external counterpulsation.
View Article and Find Full Text PDFJ Appl Physiol (1985)
January 2023
Facultad de Ciencias y Filosofía, Laboratorio de Fisiología Comparada/Laboratorio de Fisiología del Transporte de Oxígeno, Universidad Peruana Cayetano Heredia, Lima, Perú.
In chronic mountain sickness (CMS), increased blood oxygen (O)-carrying capacity due to excessive erythrocytosis (EE, [Hb] ≥ 21 g/dL) could be offset, especially during exercise by both impaired cardiac output (Q̇t) and O diffusion limitation in lungs and muscle. We hypothesized that EE results in reduced peak V̇o despite increased blood O-carrying capacity, and that isovolumic hemodilution (IVHD) improves exercise capacity. In 14 male residents of Cerro de Pasco, Peru (4,340 m), six with and eight without EE, we measured peak cycle-exercise capacity, V̇o, Q̇t, arterial blood gas parameters, and (resting) blood volume.
View Article and Find Full Text PDFJ Cereb Blood Flow Metab
January 2023
Centre for Heart, Lung and Vascular Health, University of British Columbia - Okanagan Campus, School of Health and Exercise Sciences, Kelowna, B.C., Canada, V1V 1V7.
This study investigated the influence of acute reductions in arterial O content (CaO) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO reactivity (CVR) in 11 healthy males (age; 28 ± 7 years: body mass index; 23 ± 2 kg/m). Radial artery and internal jugular vein catheters provided measurement of blood pressure and gases, quantification of cerebral metabolism, cerebral CO washout, and trans-cerebral nitrite exchange (ozone based chemiluminescence). Prior to and following haemodilution, the partial pressure of arterial CO (PaCO) was elevated with dynamic end-tidal forcing while gCBF was measured with duplex ultrasound.
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