This study examined the relationship between the Cognitive Deficit scale and psychiatric outcome in a sample of 31 first episode schizophrenics. These patients initially were evaluated during their inpatient hospitalization and thereafter assessed for psychiatric symptomatology at 3-, 6-, and 12-month intervals. At the end of 12 months, 51.6% of the sample were in remission, and 48.4% either remained in their psychotic episode during the follow-up period or relapsed. However, the two Cognitive Deficit scores obtained at baseline showed no relationship with subsequent outcome of psychiatric illness. It is suggested that this scale may not be sensitive enough to be used as a diagnostic tool with this group of patients.
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http://dx.doi.org/10.1002/1097-4679(198511)41:6<750::aid-jclp2270410604>3.0.co;2-3 | DOI Listing |
J Gerontol A Biol Sci Med Sci
January 2025
Centro de Investigación Clínica Avanzada (CICA), Hospital Clínico Universidad de Chile.
Postoperative delirium (POD), an acute cognitive dysfunction linked to morbidity and mortality, is characterized by memory impairments and disturbances in consciousness, particularly in patients aged 65 and older. Neuroinflammation and NAD+ imbalance are key mechanisms behind POD, leading to synaptic and cognitive deterioration. However, how surgery contributes to POD and neuroinflammation remains unclear, and effective treatments are lacking.
View Article and Find Full Text PDFOpen Med (Wars)
January 2025
Endocrine Department, 920th Hospital of Joint Logistics Support Force, PLA, No. 212 Daguan Road, Xishan District, Kunming, 650000, Yunnan, China.
Background: Diabetes-related cognitive impairment is increasingly recognized as a significant complication, profoundly impacting patients' quality of life. This review aims to examine the pathophysiological mechanisms, clinical manifestations, risk factors, assessment and diagnosis, management strategies, and future research directions of cognitive impairment in diabetes.
Methodology: A comprehensive literature search was conducted using PubMed, Medline, and other medical databases to identify, review, and evaluate published articles on cognitive impairment in diabetes.
PeerJ
January 2025
Department of Psychology, Aichi University of Education, Kariya, Aichi, Japan.
Background: Depression, a widespread mental health issue, is often marked by impaired cognitive control, particularly in managing proactive and reactive processes. The Dual Mechanisms of Control (DMC) framework differentiates between these two modes of cognitive control: proactive control involves sustained goal maintenance, while reactive control is more stimulus-driven and transient. Stress, known to exacerbate cognitive dysfunction in depression, may influence the balance between these control processes, though the specific effects remain poorly understood.
View Article and Find Full Text PDFBackground: Diabetes is known to cause cognitive impairments and synaptic dysfunction. This study investigates the effects of (EO), (CT), Vitamin C, and metformin on cognitive function and synaptic density (SYN) in diabetic rats. This work aims to evaluate the impact of various treatments on spatial learning, memory, and SYN in a diabetic rat model.
View Article and Find Full Text PDFCureus
December 2024
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, CHN.
Migraine, marked by moderate to severe headaches, is frequently accompanied by reversible neurological symptoms. Recent studies have revealed a complex and significant relationship between psychological factors and the onset and progression of migraine. Personality traits, such as neuroticism and harm avoidance, play a crucial role in the development, progression, and treatment outcomes of migraines.
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