AI Article Synopsis
- A structural locus for the sixth component of complement (C-6) in mice is located on chromosome 15, with the order of loci identified as C-6, Gpt-1, and Gdc-1.
- Three-point linkage analysis shows that C-6 is 25.9 cM from Gpt-1 and 36.4 cM from Gdc-1, indicating C-6 is close to the centromere.
- The text also introduces a new variant of C-6 found in AKR mice, suggested to be named C6B, with the allele encoding it referred to as C-6b.
Article Abstract
A structural locus (C-6) for the sixth component of complement in mice is assigned to chromosome 15. Three-point linkage analysis indicated that the order of loci is C-6, Gpt-1, Gdc-1, and that the map distances are 25.9 +/- 4.9 between C-6 and Gpt-1, and 36.4 +/- 5.5 between C-6 and Gdc-1. Since Gdc-1 is more distal than Gpt-1, and C-6 is 26 cM away from Gpt-1, it is estimated that the C-6 is proximal to the centromere. In addition, a new C6 form found in AKR mice is described. We propose the designation C6B for it and C-6b for the allele encoding C6B.
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| http://dx.doi.org/10.1007/BF00430312 | DOI Listing |
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Article Synopsis
- A structural locus for the sixth component of complement (C-6) in mice is located on chromosome 15, with the order of loci identified as C-6, Gpt-1, and Gdc-1.
- Three-point linkage analysis shows that C-6 is 25.9 cM from Gpt-1 and 36.4 cM from Gdc-1, indicating C-6 is close to the centromere.
- The text also introduces a new variant of C-6 found in AKR mice, suggested to be named C6B, with the allele encoding it referred to as C-6b.
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