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A Probabilistic Modeling Framework for the Prediction of Spontaneous Premature Beats and Reentry Initiation.
Heart Rhythm
January 2025
Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA. Electronic address:
Background: Spontaneously occurring life threatening reentrant arrhythmias result when a propagating premature beat encounters a region with significant dispersion of refractoriness. Although localized structural tissue heterogeneities and prescribed cell functional gradients have been incorporated into computational electrophysiological models, a quantitative framework for the evolution from normal to abnormal behavior that occurs via disease is lacking.
Objective: The purpose of this study was to develop a probabilistic modeling framework that represents the complex interplay of cell function and tissue structure in health and disease which predicts the emergence of premature beats and the initiation of reentry.
Measuring trends in extinction risk: a review of two decades of development and application of the Red List Index.
Philos Trans R Soc Lond B Biol Sci
January 2025
BirdLife International, David Attenborough Building, Pembroke Street, Cambridge CB2 3QZ, UK.
The Red List Index (RLI) is an indicator of the average extinction risk of groups of species and reflects trends in this through time. It is calculated from the number of species in each category on the IUCN Red List of Threatened Species, with trends influenced by the number moving between categories when reassessed owing to genuine improvement or deterioration in status. The global RLI is aggregated across multiple taxonomic groups and can be disaggregated to show trends for subsets of species (e.
View Article and Find Full Text PDFPharmacovigilance study of the association between progestogen and depression based on the FDA adverse event reporting System (FAERS).
Sci Rep
January 2025
Department of pharmacy, Heze University, Heze, 274000, Shandong Province, China.
Progestogens commonly used in the clinic include levonorgestrel, etonogestrel, medroxyprogesterone, hydroxyprogesterone, progesterone, desogestrel, and megestrol. Progestogens are widely used for contraception and the treatment of endometriosis, threatened abortion and other diseases. However, the correlation between progestogen use and depression is not clear.
View Article and Find Full Text PDFThe role of worldviews, radicalization risk factors, and personality in harassment of scientists.
Sci Rep
January 2025
Department of Psychology, University of Amsterdam, Nieuwe Achtergracht 129B, 1018 WS, Amsterdam, The Netherlands.
Anti-science movements brought more than public distrust in science. Perhaps even more worryingly, these movements are also associated with instances of harassment of-and violence against-scientists. However, virtually nothing is known about individuals likely to harass or harm scientists.
View Article and Find Full Text PDFExploiting the Electrostatic Binding of Ruthenium Hexamine Molecular Redox Nanowires onto DNA/OGCN Biohybrid Electrodes toward the Electrochemical Detection of COVID-19.
ACS Appl Bio Mater
January 2025
Centre for Interdisciplinary Research and Innovation (CIDRI), UPES (Bidholi), Dehradun, Uttarakhand 248007, India.
The Coronavirus Disease 2019 (COVID-19) recently emerged as a life-threatening global pandemic that has ravaged millions of lives. The affected patients are known to frequently register numerous comorbidities induced by COVID-19 such as diabetes, asthma, cardiac arrest, hypertension, and neurodegenerative diseases, to name a few. The expensiveness and probability of false negative results of conventional screening tests often delay timely diagnosis and treatment.
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