It has been shown in rabbit experiments that a 7-day administration of papaverine and pentamine in doses of 1 mg/kg without administering nicotinic (4 mg/kg) and succinic (50 mg/kg) acids and in conjunction with their administration given in courses led to a distinct change in carbohydrate-phosphorus metabolism in blood vessels of rabbits with pituitrin hypertension. The drug combination removed unfavourable metabolic shifts seen in the vessels in the experimental pathology more effectively than separate drug administration.
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It has been shown in rabbit experiments that a 7-day administration of papaverine and pentamine in doses of 1 mg/kg without administering nicotinic (4 mg/kg) and succinic (50 mg/kg) acids and in conjunction with their administration given in courses led to a distinct change in carbohydrate-phosphorus metabolism in blood vessels of rabbits with pituitrin hypertension. The drug combination removed unfavourable metabolic shifts seen in the vessels in the experimental pathology more effectively than separate drug administration.
View Article and Find Full Text PDFExperiments on rabbits with pituitrin hypertension have demonstrated activation of Na+, K+-ATPase of red cell membranes. Meanwhile ATPase activity declined in vasorenal hypertension. The vasodilatory drugs (papaverine, pentamine, euphylline, nicotinic acid) administered in courses normalized both the activity of transport ATPases of cell membranes and carbohydrate metabolism of blood vessels, which was disturbed in experimental vascular pathology.
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