The effect of inhaled verapamil and gallopamil (estimated dose 3 mg) was studied in 10 patients with exercise-induced asthma. Saline was used as a control. Verapamil and gallopamil modified exercise-induced asthma in 8 of the 10 patients and the degree of inhibition with both the drugs was comparable. Gallopamil, which is a more potent vascular smooth muscle calcium antagonist when compared to verapamil, failed to show a greater protective effect in exercise-induced asthma in the patients studied.
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