Twenty-eight undifferentiated basal-cell carcinomas were studied electron microscopically and histochemically. It is established that the cells of which the tumours are formed, retain a number of tissue- and cell-specific features of the epidermis and skin appendages cells. 4 groups of undifferentiated basal-cell carcinoma are distinguished on the basis of this study that histogenetically are connected with the cells of epidermis, hair follicle, secretory parts of the eccrine sweat or sebaceous glands respectively.
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Dermatopathology (Basel)
July 2024
Dermatology Clinic, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Int J Mol Sci
January 2024
Dermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.
Preferentially Expressed Antigen in Melanoma (PRAME), a member of the cancer/testis antigen family, is central to the field of skin cancer diagnostics and therapeutics. As a nuclear receptor and transcriptional regulator, PRAME plays a critical role in inhibiting retinoic acid signalling, which is essential for cell differentiation and proliferation. Its aberrant overexpression in various malignancies, particularly cutaneous melanoma, is associated with more aggressive tumour phenotypes, positioning PRAME as both a diagnostic and prognostic marker.
View Article and Find Full Text PDFMedicina (B Aires)
December 2023
Servicio de Cirugía General y Gastroenterología, Instituto de Enfermedades Digestivas, Hospital Italiano de Córdoba, Argentina.
Clear cell renal cell carcinoma (ccRCC) is an uncommon malignant neoplasm that accounts for 3% of all malignant tumors in adults. This tumor exhibits a high tendency to develop synchronous or metachronous metastases in different anatomical sites. Although gallbladder metastasis from ccRCC is extremely rare, sporadic cases have been reported in the medical literature.
View Article and Find Full Text PDFFASEB J
January 2024
Allergy, Inflammation & Remodelling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, National University of Ireland, Maynooth, Co. Kildare, Ireland.
MicroRNA (miRNA)-mediated mRNA regulation directs many homeostatic and pathological processes, but how miRNAs coordinate aberrant esophageal inflammation during eosinophilic esophagitis (EoE) is poorly understood. Here, we report a deregulatory axis where microRNA-155 (miR-155) regulates epithelial barrier dysfunction by selectively constraining tight junction CLDN7 (claudin-7). MiR-155 is elevated in the esophageal epithelium of biopsies from patients with active EoE and in cell culture models.
View Article and Find Full Text PDFiScience
September 2023
Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, MO 65211, USA.
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