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Simulation of Antral Conditions for Estimating Drug Apparent Equilibrium Solubility after a High-Calorie, High-Fat Meal.
Mol Pharm
January 2025
Department of Pharmacy, National and Kapodistrian University of Athens, Zografou 15771, Greece.
The simulation of antral conditions for estimating drug apparent equilibrium solubility after a high-calorie, high-fat meal is challenging. In this study, (1) we measured the apparent equilibrium solubility of two model lipophilic drugs, ketoconazole and danazol, in antral aspirates collected at various time points after a minced high-calorie, high-fat meal and a glass of water 30 min after initiation of meal administration, and we designated one point estimate for ketoconazole and one point estimate for danazol; (2) we evaluated the usefulness of FeSSGF-V2 and FEDGAS pH = 3 in reproducing the two point estimates; (3) we evaluated potential compositions of FeSSGF-V3 that simulate the pH, the buffer capacity toward both less acidic and more acidic values, and the antral lipid and protein contents with easily accessible, commercially available products, and (4) we identified the most useful composition of FeSSGF-V3 for reproducing the two point estimates. For both model drugs, apparent solubility in FeSSGF-V2 and in FEDGAS pH 3 deviated substantially from the corresponding point estimate.
View Article and Find Full Text PDFCharacterization of phospholipid profiles of egg yolks: Newly classified plasmalogens, distribution of polyunsaturated fatty acids, and the effects of dietary enrichment.
Food Chem X
January 2025
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Egg yolk phospholipids are commercially valuable products that are beneficial to human health. Previous research on phospholipids in egg yolk mainly focuses on phosphatidyl choline (PC), phosphatidyl ethanolamine (PE), and fatty acid compositions, and neglects the esterification position and other bioactive phospholipids. This study found a total of 19 classes of phospholipids and 275 subclasses using lipidomics.
View Article and Find Full Text PDFFormation of volatile compounds in salt-mediated naturally fermented cassava.
Food Chem X
January 2025
Center of Food and Fermentation Technologies (TFTAK), Mäealuse 2/4B, 12618 Tallinn, Estonia.
Cassava is a starchy staple typically consumed in tropical countries; however, its high moisture content renders it susceptible to post-harvest deterioration. Fermentation has been used to improve shelf-life, functional properties, nutrient bioavailability, minimize toxic compounds, and alter aroma. In this study, the effect of added salt (5-25 %) on the pH, titratable acidity (TTA), and volatile compounds (VOCs) in cassava fermented was investigated.
View Article and Find Full Text PDFExploring the link between soil health and crop productivity.
Ecotoxicol Environ Saf
January 2025
Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.
Understanding the complex interactions of plants and soils in the face of global food security and environmental degradation challenges is critical to the future of sustainable agriculture. This review discusses the important link between soil health and crop productivity by providing and comprehensive assessment of soil properties and management methods. By examining the physical, chemical, and biological properties of soil, it uncovers the key limitations posed by the soil environment on crop growth.
View Article and Find Full Text PDFEvaluating the bioavailability of rare earth elements in paddy soils and their uptake in rice grains for human health risk.
Environ Geochem Health
January 2025
Department of Agricultural Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Rare earth elements (REEs) are a critical global focus due to their increasing use, raising concerns about their environmental distribution and human exposure, both vital to food safety and human health. Surface soil (0-30 cm) and corresponding rice grain samples (n = 85) were collected from paddy fields in Taiwan. This study investigated the total REE contents in soil through aqua regia digestion, as well as their labile forms extracted using 0.
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