The authors studied the development of "de novo" carcinomas, i.e. carcinomas which develop directly in the mucosa without having passed via an adenomatous phase. They took into account the accompanying signs of the lesion: peri-lesional signs which always accompany carcinomas from the onset, but not adenomas. These carcinomas are always small, limited to the mucosa and non-invasive. On the basis of a statistical analysis of 2,045 carcinomas of the rectum, "de novo" carcinomas would appear to be much more common than is generally believed.
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