A 10-year-old boy with sickle cell disease developed osteomyelitis of the humerus associated with blood cultures positive for Bacteroides fragilis. Clinical and radiological resolution followed a 10-day course of intravenous clindamycin. Attention is drawn to the definite but poorly recognized association between sickle cell disease and anaerobic osteomyelitis, and the probable pathophysiology is described.
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