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XL888 and pembrolizumab modulate the immune landscape of colorectal tumors in a phase Ib/II clinical trial.
Oncoimmunology
December 2025
Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
We conducted a phase Ib/II clinical trial to evaluate the safety, feasibility, and clinical activity of combining pembrolizumab (anti-PD-1) with XL888 (Hsp90 inhibitor) in patients with advanced colorectal cancer (CRC). We hypothesized that this regimen would modulate soluble and cellular immune mediators and enhance clinical outcomes. The trial employed a 3 + 3 open-label design, with an expansion cohort at the recommended phase II dose (RP2D) in treatment-refractory, mismatch repair-proficient CRC patients.
View Article and Find Full Text PDFThe Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier.
Nutrients
February 2025
Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs impact the gut microbiome and gut barrier, emphasizing gut dysbiosis and increased gut permeability.
View Article and Find Full Text PDFIsolation and Characterization of Enterocin-Producing Strains from Algerian Traditional Food "Dried Figs Marinated in Olive Oil": Functional and Safety Evaluations.
Foods
February 2025
Higher School of Biological Sciences of Oran, BP 1042 Saim Mohamed, Cité Emir Abdelkader (EX-INESSMO), Oran 31000, Algeria.
The increasing consumer demand for natural and sustainable food preservation methods has highlighted the potential of lactic acid bacteria (LAB) and their bioactive metabolites, particularly bacteriocins, as effective antimicrobial agents. This study aimed to isolate and characterize strains from Algerian traditional dried figs marinated in olive oil, a nutrient-dense and underexplored food matrix. Twelve isolates were identified as using MALDI-TOF MS and 16S rRNA gene sequencing, ensuring precise taxonomic classification.
View Article and Find Full Text PDFAn Evaluation of a Syndromic Molecular Panel in Optimising the Microbiological Diagnosis and Antimicrobial Therapy of Suspected Osteoarticular Infections in Paediatric Patients.
Diagnostics (Basel)
February 2025
Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Paediatric osteoarticular infections (POAIs) present unique diagnostic and therapeutic challenges. Microbiological culture (MC) is typically time-consuming and lacks sensitivity, especially when patients have received antibiotics. The BIOFIRE Joint Infection Panel (BJIP) is a syndromic molecular assay for the direct identification of most pathogens causing POAIs.
View Article and Find Full Text PDFGraphene metasurfaces biosensor for COVID-19 detection in the infra-red regime.
Sci Rep
March 2025
Materials Electrochemistry Laboratory, School of Materials Science and Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
This study presents the design and analysis of a biosensor for COVID-19 detection, integrating graphene metasurfaces with gold, silver, and GST materials. The proposed sensor architecture combines a square ring resonator with a circular ring resonator, optimized through COMSOL Multiphysics simulations in the infrared regime. The sensor demonstrates exceptional performance characteristics, with absorption values exceeding 99.
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