A subinfective dose of Staphylococcus aureus (6 X 10(6)) does not produce wound infection in the rat model. Reducing the dosage (concentration) of epinephrine results in decreased numbers of viable bacteria in tissue and a lower incidence of wound infection in this model.
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http://dx.doi.org/10.1097/00006534-198512000-00024 | DOI Listing |
Infect Chemother
December 2024
Department of Microbiology, Government Medical College, Srinagar, J&K, India.
Background: Wound infections significantly impact morbidity, mortality, and healthcare costs globally. The Kashmir Valley's unique geographical and climatic conditions, coupled with resource constraints and antibiotic misuse, complicate managing these infections effectively. This study aimed to identify predominant bacterial pathogens in wound infections at a tertiary care hospital in Kashmir, determine their antibiotic susceptibility profiles, and estimate the prevalence of multidrug-resistant (MDR) strains.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Central, Guangzhou, 510260, Guangdong Province, China.
Surgical site infections (SSIs) are a significant concern following posterior lumbar fusion surgery, leading to increased morbidity and healthcare costs. Accurate prediction of SSI risk is crucial for implementing preventive measures and improving patient outcomes. This study aimed to construct and validate a nomogram predictive model for assessing the risk of SSIs following posterior lumbar fusion surgery.
View Article and Find Full Text PDFActa Ortop Mex
January 2025
Servicio de Ortopedia, Hospital de Especialidades «5 de Mayo», Instituto de Seguridad y Servicios Sociales de los Trabajadores al Servicio de los Poderes del Estado de Puebla.
Introduction: orthopedic device-associated infections (ODI) are considered surgical site infections (SSI). SSIs are generally attributed to contamination during surgery, but they require certain factors for their development. Therefore, the objective of this study was to analyze the risk factors for the development of SSIs in patients with closed fractures.
View Article and Find Full Text PDFJ Arthroplasty
January 2025
Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, Virginia, 24016, United States of America; Department of Orthopaedic Surgery, Carilion Clinic Institute for Orthopaedics & Neurosciences, 2331 Franklin Road Southwest, Roanoke, Virginia, 24014, United States of America.
Background: Preoperative malnutrition is a known risk factor for postoperative complications following total joint arthroplasty (TJA), however, there is scant literature comparing which nutritional index is best at predicting these outcomes. The purpose of this study was to investigate the utility of the Maastricht Index (MI), Onodera's Prognostic Index (OPNI), the Geriatric Nutritional Risk Index (GNRI), and a novel, modified Geriatric Nutritional Risk Index (mGNRI) in predicting periprosthetic joint infection (PJI), wound complications (WC), readmission, and reoperation rates after TJA.
Methods: A single-center, retrospective cohort study was performed of patients who underwent primary TJA from January 2016 to December 2021.
Clin Spine Surg
January 2025
Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia.
Study Design: A retrospective database study.
Objective: To compare complications and costs associated with endoscopic and open lumbar decompression on a large scale.
Background: Though open lumbar decompression is considered the gold standard, endoscopic procedures are on the rise.
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