To examine the effects of malnutrition on the ontogeny of alpha 2 noradrenergic receptor function, we compared the effects of clonidine during early development in severely malnourished and well-nourished rat pups. Independent groups of pups from dams given either 6% or 25% casein diets received one of five doses of clonidine at 5, 10, 15, 20 or 25 days of age and dose-response relationships for motor activity were determined. In the 25% pups the clonidine-induced locomotor activity was greatest at 5 and 10 days, intermediate at 15 days and not elevated at 20 and 25 days. The malnourished pups exhibited a significant delay in the transition from hyperactivity to hypoactivity, being activated by clonidine until at least 25 days. Wall-climbing measures indicated similar developmental trends as overall activity. These results are discussed in terms of the proposed mechanisms mediating the developmental change in the effects of alpha 2 receptor stimulation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0091-3057(85)90420-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nutritional Prehabilitation Intervention in Hematological Patients Undergoing Bone Marrow Transplant: A Systematic Review of the Literature.
Nutrients
December 2024
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy.
Background: Nutritional interventions play a critical role in bone marrow transplant (BMT) patients. This review evaluates the effectiveness of nutritional strategies in mitigating post-transplant malnutrition and improving clinical outcomes.
Methods: A systematic review was conducted using PubMed, CINAHL, Cochrane Library, and Embase.
Vitamin D Status in Roma Mothers and Newborns: Socioeconomic Factors and Impact on Neonatal Outcome.
Nutrients
December 2024
Department of Obstetrics and Gynecology 2, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540136 Târgu Mureș, Romania.
Background: The Roma are a socioeconomically disadvantaged, marginalized community with reduced access to education, social services, and healthcare. Despite the known health risks they are exposed to, we have limited data about a wide range of health outcomes in this population, including vitamin D deficiency. The aim of this study was to investigate prevalence of vitamin D deficiency and its impact on the anthropometric outcomes of newborns in a group of Roma mothers and their infants in Romania.
View Article and Find Full Text PDF/ Infection: Is It Still a Concern?
Microorganisms
December 2024
Pediatric Infectious Disease Unit, Barilla Children's Hospital of Parma, 43126 Parma, Italy.
Campylobacteriosis is a leading cause of infectious diarrhea and foodborne illness worldwide. infection is primarily transmitted through the consumption of contaminated food, especially uncooked meat, or untreated water; contact with infected animals or contaminated environments; poultry is the primary reservoir and source of human transmission. The clinical spectrum of / infection can be classified into two distinct categories: gastrointestinal and extraintestinal manifestations.
View Article and Find Full Text PDFAssessment of the Diagnostic Performance of MUAC in Malnutrition Screening and Its Correlation with Other Anthropometric Indicators in Healthy Children and Adolescents.
Children (Basel)
December 2024
Division of Social Pediatrics, Department of Pediatrics, Faculty of Medicine, Children's Hospital, Ege University, 35100 Izmir, Turkey.
Background/objectives: This study aimed to evaluate the correlation of mid-upper arm circumference (MUAC) z-scores with body mass index (BMI) and weight-for-height (WFH) z-scores to determine its reliability in identifying malnutrition and its potential in clinical practice in healthy children and adolescents.
Methods: Our study included 906 healthy children and adolescents aged between 2 months and 18 years who were admitted to University Hospital's General Pediatrics Clinic and attended 12 primary schools in 6 additional Izmir provinces. Anthropometric measurements (weight, length/standing height, MUAC, BMI, WFH) were performed.
Role of Human Milk Microbiota in Infant Neurodevelopment: Mechanisms and Clinical Implications.
Children (Basel)
November 2024
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16126 Genoa, Italy.
Background: Human milk (HM) is recognized as an ideal source of nutrition for newborns; as a result, its multiple bioactive molecules can support the growth of healthy newborns and reduce the risk of mortality and diseases such as asthma, respiratory infections, diabetes (type 1 and 2), and gastrointestinal disorders such as ulcerative colitis and Crohn's disease. Furthermore, it can reduce the severity of necrotizing enterocolitis (NEC) in preterm infants. Moreover, human milk oligosaccharides (HMOs) present in breast milk show an immunomodulatory, prebiotic, and neurodevelopmental effect that supports the microbiota-gut-brain axis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!