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New insights into benzo[⍺]pyrene osteotoxicity in zebrafish.
Ecotoxicol Environ Saf
December 2021
Centre of Marine Sciences (CCMAR), University of Algarve, Faro, Portugal. Electronic address:
Persistent and ubiquitous organic pollutants, such as the polycyclic aromatic hydrocarbon benzo[⍺]pyrene (BaP), represent a major threat to aquatic organisms and human health. Beside some well-documented adverse effects on the development and reproduction of aquatic organisms, BaP was recently shown to affect fish bone formation and skeletal development through mechanisms that remain poorly understood. In this work, zebrafish bone-related in vivo assays were used to evaluate the osteotoxic effects of BaP during bone development and regeneration.
View Article and Find Full Text PDFSome outcomes and a hypothetical mechanism of combined lead and benzo(a)pyrene intoxication, and its alleviation with a complex of bioprotectors.
Toxicol Rep
August 2020
The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Ekaterinburg, Russia.
Rats were exposed 3 times a week during 6 weeks to repeated intraperitoneal injections of lead acetate solution in water (Pb) and/or benzo(а)pyrene solution in petrolatum oil (B(а)P) in various dose ratios. Towards the end of the period, the animals developed a moderate subchronic intoxication having some features characteristic of lead effects. The type of combined toxicity estimated with the help of isoboles constructed by the Response Surface Methodology was found to be varied depending on a particular effect, its level, and dose ratio.
View Article and Find Full Text PDFBenzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.
BMC Genomics
October 2014
Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment & Health, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
Background: Gene expression changes induced by carcinogens may identify differences in molecular function between target and non-target organs. Target organs for benzo[a]pyrene (BaP) carcinogenicity in mice (lung, spleen and forestomach) and three non-target organs (liver, colon and glandular stomach) were investigated for DNA adducts by 32P-postlabelling, for gene expression changes by cDNA microarray and for miRNA expression changes by miRNA microarray after exposure of animals to BaP.
Results: BaP-DNA adduct formation occurred in all six organs at levels that did not distinguish between target and non-target.
[Malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene].
Wei Sheng Yan Jiu
May 2001
Institute for Chemical Carcinogenesis, Guangzhou Medical College, Guangzhou 510182, China.
The malignant transformation of human bronchial epithelial cell 16HBE induced by benzo (a) pyrene metabolite--dihydroxyepoxy benzo pyrene (BPDE) was studied. 16HBE cells were treated several times with BPDE at different concentrations in vitro. The identification on the malignancy of transformed 16HBE cells was investigated.
View Article and Find Full Text PDF[Cloning of differentially expressed cDNA sequences involved in malignant transformation induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene].
Zhonghua Zhong Liu Za Zhi
May 2002
Chemical Carcinogenesis Institute, Guangzhou Medical College, Guangzhou 510182, China.
Objective: To clone differentially expressed cDNA sequences involved in malignant transformation induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene (BPDE).
Method: The malignant transformation of human bronchial epithelial cell line 16HBE induced by BPDE in vitro was used as a model for comparing gene expression between the transformed cells and controls. cDNA representational difference analysis (cDNA-RDA) was performed to isolate differentially expressed cDNA fragment in transformed cells.
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