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Notch Inhibitors and BH3 Mimetics in T-Cell Acute Lymphoblastic Leukemia.
Int J Mol Sci
November 2024
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with poor response to conventional therapy, derived from hematopoietic progenitors committed to T-cell lineage. Relapsed/Refractory patients account for nearly 20% of childhood and 45% of adult cases. Aberrant Notch signaling plays a critical role in T-ALL pathogenesis and therapy resistance.
View Article and Find Full Text PDFTemporal Order and Developmental Context of Aggressive Attitude and Aggressive Behavior: Testing a Within-Person Reciprocal Effects Model.
J Adolesc
December 2024
Department of Criminal Justice, Kutztown University, Kutztown, Pennsylvania, USA.
Introduction: The purpose of this study was to determine whether the relationship between aggressive attitude and aggressive behavior is reciprocal or bidirectional in nature.
Method: A sample of 845 early adolescent youth (406 boys, 439 girls) between the ages of 10 and 13 (mean = 11.21) served as participants in this study.
enhances virulence by progressive generation of new phenotypes.
Curr Res Microb Sci
November 2024
Bacterial infections and antimicrobial therapies group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac Street 10, 08037, Barcelona, Spain.
and have been co-isolated from several biofilm-associated diseases, including those related to medical devices. This association confers advantages to both microorganisms, resulting in detrimental effects on the host. To elucidate this phenomenon, the present study investigated colony changes derived from non-physical interactions between and .
View Article and Find Full Text PDFExtracellular nicotinamide phosphoribosyltransferase (eNAMPT) drives abnormal pericyte-rich vasculature in triple-negative breast cancer.
Angiogenesis
December 2024
Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy.
Article Synopsis
- - Tumour angiogenesis is crucial for supplying malignant cells with oxygen and nutrients, facilitating their invasion and spread, often resulting in the formation of disorganized and leaky blood vessels due to cytokine activity.
- - Nicotinamide phosphoribosyltransferase (eNAMPT) is elevated in many cancers, acting not only as a necessary enzyme for energy production but also as a pro-inflammatory cytokine that correlates with cancer aggressiveness and prognosis, especially in breast cancer.
- - In triple-negative breast cancer, eNAMPT promotes angiogenesis and metastasis by attracting NG2 pericytes and activating pro-inflammatory signaling, with potential therapeutic effects demonstrated by neutralizing eNAMPT with an antibody, pointing towards new anti-
Post-Neutralisation Activated Clotting Time and Postoperative Transfusions in Cardiac Surgery Outcome.
J Coll Physicians Surg Pak
November 2024
Department of Anaesthesia, The Aga Khan University Hospital, Karachi, Pakistan.
Article Synopsis
- The study aimed to evaluate how post-protamine neutralisation activated clotting time (ACT) influences outcomes in cardiac surgery, like chest drain output, blood transfusion needs, and ICU stay.
- Conducted at The Aga Khan University Hospital from February to August 2023, it involved analyzing data from 101 elective cardiac surgery patients, split into two groups based on their ACT values.
- Results showed no significant differences in postoperative outcomes or transfusion needs between the two groups, indicating that maintaining ACT close to baseline might be beneficial without requiring aggressive treatment.
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