AI Article Synopsis
- The study investigated the effects of pilocarpine on rabbits, measuring drug levels in the aqueous humor and observing changes in pupil size and intraocular pressure (IOP) after single drop instillation.
- Higher concentrations of pilocarpine led to increased drug levels, but this increase wasn't consistently significant nor proportional to the dosage.
- The presence of contact lenses influenced pilocarpine levels over time, showing reduced concentrations at two hours, but did not affect the overall miosis or IOP measurements during the study.
Article Abstract
Following single drop instillation of pilocarpine, drug levels in individual aqueous humor samples of rabbits were determined by high-performance liquid chromatography and correlated with changes in pupillary diameter and intraocular pressure (IOP). Application of higher concentrations of pilocarpine resulted in higher drug levels but these differences were neither statistically significant nor consistently proportional to the strength applied. Maximum miosis occurred between 30 and 60 minutes and the maximum fall in IOP occurred between 1 and 2 hours. The influence of contact lenses with varying water content and thickness upon intraocular penetration of pilocarpine was studied. Contact lenses did not affect 30-minute concentrations of pilocarpine in aqueous humor. Although two-hour levels were significantly lower with contact lenses, miosis and IOP at these time periods were comparable with and without lenses. Neither water content nor thickness appreciably influenced miosis and IOP.
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| http://dx.doi.org/10.3109/02713688509003349 | DOI Listing |
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