Certain general problems on foundation of the hormonal regulation mechanisms during the prenatal and early postnatal ontogenesis are discussed basing on the authors' own results and on the literature data. They concern development of the hypophysis and peripheral target-glands in immaturely-bone Mammalia and fowls. The data on foundation of the endocrine glands functional activity are compared in rats and hens. The notion on a relative autonomous hormonal function of the peripheral endocrine glands at early stages of ontogenesis is motivated.

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