Conditions for the appearance of adifferentiated nocardioform variants of Streptomyces roseoflavus var. roseofungini.

It was shown that adifferentiated nocardioform variants (NV) of Streptomyces roseoflavus var. roseofungini 1128 may appear in mycelial cell suspensions of submerged actinomycete cultures in water, phosphate buffer, and water with fructose (1%) or glucose (1%), as well as in mycelia of old (10-30 days) cultures on different carbon sources. When sugars, alcohols, or amino acids were added to a medium with fructose, NV formation was inhibited, but not completely suppressed. Fructose was shown to be the most potent factor in the appearance of NV.