The CO2 laser was used to treat 300 patients with cervical intra-epithelial neoplasia (CIN). The patient characteristics, histological features, complications and follow-up are described and our experience is discussed. The CO2 laser appears to be safe and efficient for outpatient treatment of CIN, with a cure rate of 94%.
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J Infect Public Health
January 2025
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address:
Background: CareHPV is a highly promising screening HPV assay that functions as a simplified and rapid point-of-care test, making it particularly well-suited for low-resource areas. It exhibits high sensitivity for detecting cervical precancerous lesions in cross-sectional study design. However, there is still limited evidence on the long-term protection of careHPV testing in the practical setting.
View Article and Find Full Text PDFInt J Gynecol Cancer
September 2024
Lower Genital Tract Disease Center, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, Shanghai, China
Objective: To investigate the high-risk factors associated with concurrent cervical intra-epithelial neoplasia (CIN) and vaginal intra-epithelial neoplasia (VaIN) in patients with high-grade lesions.
Methods: This retrospective study at the Obstetrics and Gynecology Hospital of Fudan University included patients diagnosed with concurrent CIN2/3 and VaIN2/3 (concurrent group) over the period from January 1, 2019, to December 31, 2019. Patients with only CIN2/3 during the corresponding period were selected chronologically on a 1:2 basis (CIN group).
NPJ Precis Oncol
June 2024
Tissue Image Analytics Centre, Department of Computer Science, University of Warwick, Coventry, UK.
Oral epithelial dysplasia (OED) is a premalignant histopathological diagnosis given to lesions of the oral cavity. Its grading suffers from significant inter-/intra-observer variability, and does not reliably predict malignancy progression, potentially leading to suboptimal treatment decisions. To address this, we developed an artificial intelligence (AI) algorithm, that assigns an Oral Malignant Transformation (OMT) risk score based on the Haematoxylin and Eosin (H&E) stained whole slide images (WSIs).
View Article and Find Full Text PDFArch Gynecol Obstet
July 2024
Department of Obstetrics and Gynecology, University Hospitals of Leuven (UZ Leuven), Herestraat 49, 3000, Louvain, Belgium.
Objective: Investigate the association between p16/Ki-67 dual stain cytology test (DST) results, obtained prior to- and 6 months after LLETZ surgery for treatment of CIN, and the follow-up regimen three years after treatment.
Methods: Secondary analysis of a prospective cohort study. Cervical cytology samples were obtained just prior to- and 6 months after LLETZ and underwent conventional liquid-based cytology (LBC) and p16/Ki-67 dual staining, as well as high-risk HPV genotyping.
J Cytol
April 2024
Department of Medical Technology, The Graduate School of Ehime Prefectural University of Health Sciences, Ehime, Japan.
Aims: The present study aimed to investigate whether the presence of mitoses in hyperchromatic crowded groups (HCGs) in cervical cytological specimens can serve as cytological criteria for high-grade squamous intra-epithelial lesions (HSILs).
Methods And Material: Various parameters were examined, including the frequency of mitotic figures per high power field (HPF) in Pap, hematoxylin eosin (HE) samples, and PHH3 immunocytochemical (ICC) and immunohistochemical (IHC) analyses.
Results: In the Pap and PHH3-ICC samples, the number of mitotic figures observed in HCGs was significantly higher in HSIL ( < 0.
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