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Effects of aqueous dicaine and pyromecaine solutions on mucosal tissue structures were studied in 40 syrian hamsters. The results evidence that when dicaine, an ether anesthetic, is applied, injuries prevail over reactive phenomena: a manifest cytotoxic effect of the drug can be seen at all phases of the follow-up, this effect being observed both in the mucosal epithelium and in the deeper layers of the mucosa. An amide anesthetic, pyromecaine, is not characterized by a cytotoxic action on mucosal epithelium cells, though in later periods of the experiment it also may induce side effects presenting as an acute inflammatory reaction developing in the subepithelial [correction of polyepithelial] connective tissue stroma and muscular layer.
View Article and Find Full Text PDF[The action of aqueous solutions of dicaine and pyromecaine on the epithelium of the oral mucosa].
Stomatologiia (Mosk)
September 1990
Buccal mucosa epithelium was studied by the cytological method in 70 patients before and after applications of 3% dicain and 2% pyromecain solutions. A statistically significant increase in the count of dissociated cells with altered nuclei and lysed cells were observed after application of 3% dicain, particularly so in the patients with aggravated case histories (i.e.
View Article and Find Full Text PDFThe treatment with pyromecaine and pyrroxan for 5 days was found to prevent disturbances of the physicochemical properties and the composition of the components of actomyosin complex of the rat heart left ventricle caused by experimental myocardial ischemia. Pyrroxan is able to change also the gene expression thereby leading to the appearance of a new isoform of myocardial myosin reminding by its characteristics the isoform of myosin of the rapidly contracting skeletal muscles.
View Article and Find Full Text PDF[Interaction of quinidine, lidocaine, tricaine and pyromecaine with heparin].
Farmakol Toksikol
December 1989
In the experiments on rabbits it was shown that quinidine administered intravenously in a dose of 5 mg/kg exerts no effect on the blood coagulability but decreases the degree and duration of the anticoagulant effect of heparin. Lidocaine, trimecaine and pyromecaine at the same dose alter neither the blood coagulability nor the anticoagulant effect of heparin.
View Article and Find Full Text PDFAntianginal treatment of animals with experimentally induced myocardial ischemia produced significant effects on the quantitative and qualitative composition of phospholipids: total phospholipids returned to normal levels, cardiolipins and phosphatidilinosytes were drastically increased. In ischemia, this lipid metabolism derangement appears to be of great significance as it enables the physiochemical status of biological membranes to be relatively stabilized, which is an essential condition for the enzymic system of cardiomyocytes to act.
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