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Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity.
MAbs
December 2025
Ichnos Glenmark Innovation, New York, NY, USA.
ISB 1442 is a bispecific biparatopic antibody in clinical development to treat hematological malignancies. It consists of two adjacent anti-CD38 arms targeting non-overlapping epitopes that preferentially drive binding to tumor cells and a low-affinity anti-CD47 arm to enable avidity-induced blocking of proximal CD47 receptors. We previously reported the pharmacology of ISB 1442, designed to reestablish synthetic immunity in CD38+ hematological malignancies.
View Article and Find Full Text PDFF-FDG PET/CT in Inflammation and Infection: Procedural Guideline by the Korean Society of Nuclear Medicine.
Nucl Med Mol Imaging
February 2025
Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351 Republic of Korea.
Abstract: This guideline outlines the use of F-fluoro-2-deoxyglucose positron emission tomography / computed tomography for the diagnosis and management of infectious and inflammatory diseases. It provides detailed recommendations for healthcare providers on patient preparation, imaging procedures, and the interpretation of results. Adapted from international standards and tailored to local clinical practices, the guideline emphasizes safety, quality control, and effective use of the technology in various conditions, including spinal infections, diabetic foot, osteomyelitis, vasculitis, and cardiac inflammation.
View Article and Find Full Text PDFOxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis.
Front Pharmacol
January 2025
School of Basic Medical Sciences, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Introduction: Oxyresveratrol (ORes) exhibits significant anticancer activity, particularly against breast cancer. However, its exact mechanism of action (MOA) remains unclear. This study aimed to investigate the pharmacological activity and underlying MOA.
View Article and Find Full Text PDFComputational new approach methods guide focused testing and enhance understanding of chlorantraniliprole toxicity across species.
Environ Toxicol Chem
January 2025
Great Lakes Toxicology and Ecology Division, US Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Duluth, MN, United States.
Diamide insecticides, specifically chlorantraniliprole (CHL), have been rising in popularity over the past decade, becoming one of the most widely used insecticide classes globally. These insecticides target the ryanodine receptor (RyR), primarily for control of lepidopteran agricultural pests. Field studies have revealed that some lepidopteran species have developed mutations where a methionine in a particular position (e.
View Article and Find Full Text PDFBiokinetic soft-sensing using Thiothrix and Ca. Microthrix bacteria to calibrate secondary settling, aeration and NO emission digital twins.
Water Res
January 2025
Department of Chemical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK; SWING - Department of Built Environment, Oslo Metropolitan University, St Olavs plass 0130, Oslo, Norway. Electronic address:
Climate resilience in water resource recovery facilities (WRRFs) necessitates improved adaptation to shock-loading conditions and mitigating greenhouse gas emission. Data-driven learning methods are widely utilised in soft-sensors for decision support and process optimization due to their simplicity and high predictive accuracy. However, unlike for mechanistic models, transferring machine-learning-based insights across systems is largely infeasible, which limits communication and knowledge sharing.
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