Over a period of 3 months weekly intraarticular injections of fenbufen into the knee joint of hens did not induce any significant degenerative alterations of the articular cartilage. Experimental osteoarthrosis biochemically induced by iodoacetate in the knee joint of our laboratory animals was not enhanced by weekly intraarticular applications of fenbufen or its metabolite biphenyl-acetic acid. Joint space measurements as well as other radiological and macroscopical examinations of the knee joints confirmed that fenbufen and biphenyl-acetic acid had no negative influence on articular cartilage. In this respect these antiphlogistic agents differ from many other antiinflammatory drugs and may be particularly useful in the treatment of inflammatory phases of osteoarthrosis.
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