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Evaluation of IRF7 mRNA and its Association with Promoter Methylation in Kashmiri (North-Indian) Patients with Systemic Sclerosis: A Case-Control Study.
Mediterr J Rheumatol
December 2024
Department of Immunology & Molecular Medicine.
Introduction: The interferon regulatory factor 7 (IRF7), a member of the IRF family of transcription factors, plays a major role in the regulation of numerous aspects of an immune response and has increasingly been surveyed to determine the aetiology and pathogenesis of systemic sclerosis (SSc). Objective: This study aimed to investigate the transcriptional levels of IRF7 mRNA in peripheral blood mononuclear cells (PBMCs) and the impact of promoter methylation on IRF7 mRNA expression in SSc patients compared to healthy controls.
Methods: PBMCs were obtained from confirmed 40 naïve SSc cases and 20 healthy controls for IRF-7 expression and methylation analysis.
Circinate balanitis: Early manifestation of reactive arthritis? A case series.
Indian J Sex Transm Dis AIDS
December 2024
Department of Dermatology, Venereology, Leprology, GMERS Medical College, Sola, Ahmedabad, Gujarat, India.
Circinate balanitis, although a common cutaneous manifestation of reactive arthritis (ReA), is usually an associated finding present along with the triad of arthritis, conjunctivitis, and urethritis. It is rarely seen as the only or the preceding manifestation of ReA. Here, we report three cases of circinate balanitis as stand-alone and initial presentation of probable ReA without any other symptoms of arthritis and conjunctivitis at the time of presentation.
View Article and Find Full Text PDFSuperficial arteriovenous malformations are rare fast-flow lesions. They consist of arteriovenous shunts, without cellular hyperplasia or proliferation, which develop in the surrounding tissues (cutaneous, subcutaneous, muscular, bone). Although benign, they are among the most severe of superficial malformations.
View Article and Find Full Text PDFRecurrent ulcerative tubular apocrine adenoma of the eyelid mimicking eyelid malignancy: A case report and literature review.
Int J Surg Case Rep
January 2025
King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Electronic address:
Introduction: The eyelid is a common site for cutaneous tumors; however, tubular apocrine adenoma is a rare presentation. The clinical presentation is variable and surgical excision is effective with low risk for recurrence.
Presentation Of Case: We report a 40-year-old female with recurrent tubular apocrine adenoma of eyelid mimicking eyelid malignancy.
Coagulation abnormalities following brown recluse spider (Loxosceles reclusa) envenomation: A description of 2 cases and review of the literature.
Am J Clin Pathol
January 2025
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, US.
Objective: Hemostatic abnormalities, including disseminated intravascular coagulation (DIC), are often cited as a common finding in patients following Loxosceles spider envenomation (ie, loxoscelism). The prevalence and severity of coagulopathy, however, particularly following L reclusa (ie, brown recluse) envenomation, is not well described. This study aimed to characterize coagulation laboratory parameters and coagulopathy in patients following L reclusa envenomation.
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