Rats with spontaneous hypertension versus normotensive rats showed the development of erythrocytosis, an intensification of the erythropoietic properties of the blood plasma and an increase of the 2,3-DPG concentration in the red blood cells. An enhanced production of erythropoietin, a humoral stimulator of erythropoiesis, seems to be one of the causes of the erythrocytosis development in spontaneously hypertensive rats. An increase in the 2,3-DPG concentration in the erythrocytes is an important physiological mechanism ensuring the appropriate oxygen supply to tissues.
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