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Liposomes loaded with daunorubicin and an emetine prodrug for improved selective cytotoxicity towards acute myeloid leukaemia cells.
Int J Pharm
January 2025
Centre for Pharmacy, Department of Clinical Science, University of Bergen, Norway. Electronic address:
The backbone of induction therapy in acute myeloid leukaemia (AML) is to use an anthracycline in combination with cytarabine. Despite recent advances in AML therapy, this treatment remains the standard, and it has been largely unchanged for decades. There are few curative options for patients unfit for this treatment.
View Article and Find Full Text PDFIntegrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer.
Mol Oncol
November 2024
Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Korea.
Anaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK. However, continuous treatment with ALKis invariably leads to acquired resistance in cancer cells. In this study, we propose an efficient strategy to suppress ALKi resistance through a meta-analysis of transcriptome data from various cell models of acquired resistance to ALKis.
View Article and Find Full Text PDFThe Golgi Ca stores, and original contributions by Prof. Shao Bai Xue.
Biophys Rep
October 2024
College of Life Sciences, Beijing Normal University, Beijing 100875, China.
The Golgi apparatus serves as a distinct part of intracellular Ca stores. Here, the early discovery by Professor Shao Bai Xue is reviewed, and the recent progress in the field is outlined. Golgi Ca stores-related functional proteins, such as secretory pathway Ca ATPases (SPCA1/2) and the Golgi-specific Ca releasing channel Golgi anti-apoptotic protein (GAAP), as well as the recently defined Golgi-specific Ca release agent emetine, collectively corroborate the concept of the Golgi apparatus as unique internal Ca stores.
View Article and Find Full Text PDFDual effects of ipecac alkaloids with potent antiviral activity against foot-and-mouth disease virus as replicase inhibitors and direct virucides.
Int J Vet Sci Med
October 2024
Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Foot-and-Mouth Disease (FMD) is a contagious, blistering disease caused by the Foot-and-Mouth Disease virus (FMDV), which affects livestock globally. Currently, no commercial antiviral agent is available for effective disease control. This study investigated the antiviral potential of natural-derived alkaloids against FMDV in BHK-21 cells.
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