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Preventive Lipid-Lowering Therapy and Interactions With Health Care in Patients Who Develop Premature Coronary Artery Disease.
JACC Adv
January 2025
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
Background: Rates of premature coronary artery disease (CAD) are stagnant, and the prevalence of cardiovascular risk factors in young and middle-aged adults is increasing. Lipid-lowering therapy (LLT) is effective in preventing CAD but is underutilized in younger patients. The reasons for and consequences of this underutilization are not fully understood.
View Article and Find Full Text PDFConventional and regionally distinctive risk factors for first-onset myocardial infarction: the Bangladesh Risk of Acute Vascular Events (BRAVE) case-control study.
Lancet Reg Health Southeast Asia
January 2025
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Background: South Asians may be particularly susceptible to premature myocardial infarction (MI) owing both to conventional cardiovascular risk factors and practices distinctive to South Asia. Identifying modifiable risk factors for MI in these populations could inform prevention strategies. We have, therefore, studied conventional risk factors and other characteristics in relation to occurrence of first MI in Bangladesh.
View Article and Find Full Text PDFEnvironmental impact of commonly used anaesthetic agents: systematic literature review with narrative synthesis.
BJA Open
March 2025
Department of Anaesthesia, The William Harvey Hospital, Ashford, UK.
Background: Increasing awareness of the potential environmental impact of volatile anaesthetic agents has stimulated increased use of total i.v. anaesthesia.
View Article and Find Full Text PDFHighly oxygenated cyclohexenes from the leaves of Roxb. ex Hornem and their cytotoxic and -glucosidase inhibitory activities.
Heliyon
January 2025
Center of Chemical Innovation for Sustainability (CIS), and School of Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand.
Phytochemical investigation of the leaf extract of Roxb. ex Hornem led to the isolation and identification of two new highly oxygenated cyclohexenes, uvariagrandols A () and B (), together with seven known compounds (-). Their structures were elucidated by spectroscopic methods as well as comparisons made from the literature.
View Article and Find Full Text PDFPatient-reported outcome measures for life participation in patients with chronic kidney disease: a systematic review.
Clin Kidney J
January 2025
Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia.
Background: The symptoms, comorbidities and treatment burden associated with chronic kidney disease (CKD) can be debilitating and limit life participation in patients with CKD not requiring kidney replacement therapy (KRT). The aim of this study was to identify the characteristics, content and psychometric properties of patient-reported outcome measures (PROMs) used to assess life participation in patients with CKD.
Methods: We searched MEDLINE, Embase, PsycINFO and CINAHL from database inception to February 2023 for all studies that reported life participation in patients with CKD (stages 1-5 not requiring kidney replacement therapy).
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