Fluorescent microscopy and spectrofluorometry of biogenic amines were employed to study the peripheral catecholaminergic systems in immobilized rats which received sodium hydroxybutyrate. The content of catecholamines was measured in the adrenergic nerves of dura mater, vas deferens and chromaffin tissue of the adrenals. It was established that sodium hydroxybutyrate in a dose of 40 mg/kg intraperitoneally promoted returning to normal of the adrenergic mediator activity during alarm and resistance stages. The role of the peripheral catecholaminergic systems in the mechanism of the stress-protective effect of sodium hydroxybutyrate is discussed.

Download full-text PDF

Source

Publication Analysis

Top Keywords

peripheral catecholaminergic
12
catecholaminergic systems
12
sodium hydroxybutyrate
12
[state peripheral
4
systems pharmacologic
4
pharmacologic correction
4
correction immobilization
4
immobilization stress
4
sodium
4
stress sodium
4

Similar Publications

A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs.

Life (Basel)

January 2025

Laboratory of Toxicology and Risk Assessment, Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università degli Studi di Milano, 20133 Milan, Italy.

Nucleic acid (NA)-based drugs are promising therapeutics agents. Beyond efficacy, addressing safety concerns-particularly those specific to this class of drugs-is crucial. Here, we propose an in vitro approach to screen for potential adverse off-target effects of NA-based drugs.

View Article and Find Full Text PDF

The immune system shapes body metabolism, while interactions between peripheral neurons and immune cells control tissue homeostasis and immunity. However, whether peripheral neuroimmune interactions orchestrate endocrine system functions remains unexplored. After fasting, mice lacking type 2 innate lymphoid cells (ILC2s) displayed disrupted glucose homeostasis, impaired pancreatic glucagon secretion, and inefficient hepatic gluconeogenesis.

View Article and Find Full Text PDF

Noradrenaline modulates sensory information in mouse vomeronasal sensory neurons.

iScience

October 2024

Neurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, 34136 Trieste, Italy.

Article Synopsis
  • The sympathetic nervous system enhances sensory detection and prepares organs for alertness, influencing how we sense our environment.
  • The study focused on noradrenaline (NA) and its effect on vomeronasal sensory neurons (VSNs), which are crucial for sensing pheromones and other chemical signals.
  • Findings revealed that NA boosts the activity of VSNs through alpha 1 adrenergic receptors, indicating a significant role of NA in regulating sensory processing and the connection between the sympathetic system and chemosensation.
View Article and Find Full Text PDF

Human induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) isolated from two related patients diagnosed with either idiopathic ventricular fibrillation or catecholaminergic polymorphic ventricular tachycardia, carrying an unknown variant in the RYR2 gene, c.14201A>G (p.Y4734C) and one healthy related individual.

View Article and Find Full Text PDF

Neuregulin4-ErbB4 signalling pathway is driven by electroacupuncture stimulation to remodel brown adipose tissue innervation.

Diabetes Obes Metab

September 2024

Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, China.

Article Synopsis
  • The study investigates how electroacupuncture stimulation (ES) affects sympathetic innervation in brown adipose tissue (BAT) through the BMP8B-NRG4-ErbB4 signaling pathway, with different effects depending on the stimulation site.
  • Mice fed a high-fat diet were used to measure BAT thermogenesis and metabolism, revealing that ES on forelimbs and abdomen significantly increased sympathetic nerve activity (SNA), while hindlimb stimulation had limited effects.
  • Results indicated that ES enhances catecholaminergic signals in BAT via specific neural pathways and that blocking ErbB4 disrupts the metabolic benefits of ES, highlighting the potential of ES in improving BAT function.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!